ID   AES1_SCHPO              Reviewed;         296 AA.
AC   Q8NIL3;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Antisense-enhancing sequence 1;
DE            EC=5.1.-.-;
DE   AltName: Full=AES factor 1;
GN   Name=aes1; ORFNames=SPBPB21E7.07;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=12034844; DOI=10.1093/nar/30.11.2546;
RA   Raponi M., Arndt G.M.;
RT   "Dominant genetic screen for cofactors that enhance antisense RNA-mediated
RT   gene silencing in fission yeast.";
RL   Nucleic Acids Res. 30:2546-2554(2002).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: May have isomerase activity (By similarity). Enhances target
CC       gene silencing when coexpressed with antisense RNA. {ECO:0000250,
CC       ECO:0000269|PubMed:12034844}.
CC   -!- SIMILARITY: Belongs to the PhzF family. {ECO:0000305}.
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DR   EMBL; CU329671; CAD31747.1; -; Genomic_DNA.
DR   RefSeq; NP_001018772.1; NM_001020947.2.
DR   AlphaFoldDB; Q8NIL3; -.
DR   SMR; Q8NIL3; -.
DR   BioGRID; 280253; 2.
DR   STRING; 4896.SPBPB21E7.07.1; -.
DR   iPTMnet; Q8NIL3; -.
DR   MaxQB; Q8NIL3; -.
DR   PaxDb; Q8NIL3; -.
DR   EnsemblFungi; SPBPB21E7.07.1; SPBPB21E7.07.1:pep; SPBPB21E7.07.
DR   GeneID; 3361177; -.
DR   KEGG; spo:SPBPB21E7.07; -.
DR   PomBase; SPBPB21E7.07; aes1.
DR   VEuPathDB; FungiDB:SPBPB21E7.07; -.
DR   eggNOG; KOG3033; Eukaryota.
DR   HOGENOM; CLU_048756_0_0_1; -.
DR   InParanoid; Q8NIL3; -.
DR   OMA; CHAWLQA; -.
DR   PhylomeDB; Q8NIL3; -.
DR   PRO; PR:Q8NIL3; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0016853; F:isomerase activity; IBA:GO_Central.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0031048; P:heterochromatin assembly by small RNA; IMP:UniProtKB.
DR   InterPro; IPR003719; Phenazine_PhzF.
DR   PANTHER; PTHR13774; PTHR13774; 1.
DR   Pfam; PF02567; PhzC-PhzF; 1.
DR   PIRSF; PIRSF016184; PhzC_PhzF; 1.
DR   TIGRFAMs; TIGR00654; PhzF_family; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..296
FT                   /note="Antisense-enhancing sequence 1"
FT                   /id="PRO_0000162386"
FT   ACT_SITE        47
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   296 AA;  32229 MW;  4642DFC53A7B9B91 CRC64;
     MTEHSFKQID VFSNKGFRGN PVAVFFDADN LSQKEMQQIA KWTNLSETTF VQKPTIDKAD
     YRLRIFTPEC ELSFAGHPTI GSCFAVVESG YCTPKNCKII QECLAGLVEL TIDGEKDEDT
     WISFKLPYYK ILQTSETAIS EVENALGIPL NYSSQVSPPV LIDDGPKWLV IQLPNATDVL
     NLVPKFQSLS QVCKNNDWIG VTVFGELGKD SFESRSFAPL IHVNEDPACG SGAGAVGVYI
     GSSQKTPTSL SFTISQGTKL SRQAISKVSV DVSSNKSIAV FVGGQAKTCI SGKSFI