EFP_STAA8
ID EFP_STAA8 Reviewed; 185 AA.
AC Q2FY41;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Elongation factor P {ECO:0000255|HAMAP-Rule:MF_00141};
DE Short=EF-P {ECO:0000255|HAMAP-Rule:MF_00141};
GN Name=efp {ECO:0000255|HAMAP-Rule:MF_00141};
GN OrderedLocusNames=SAOUHSC_01625;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: Involved in peptide bond synthesis. Stimulates efficient
CC translation and peptide-bond synthesis on native or reconstituted 70S
CC ribosomes in vitro. Probably functions indirectly by altering the
CC affinity of the ribosome for aminoacyl-tRNA, thus increasing their
CC reactivity as acceptors for peptidyl transferase. {ECO:0000255|HAMAP-
CC Rule:MF_00141}.
CC -!- PATHWAY: Protein biosynthesis; polypeptide chain elongation.
CC {ECO:0000255|HAMAP-Rule:MF_00141}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00141}.
CC -!- SIMILARITY: Belongs to the elongation factor P family.
CC {ECO:0000255|HAMAP-Rule:MF_00141}.
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DR EMBL; CP000253; ABD30703.1; -; Genomic_DNA.
DR RefSeq; WP_000626504.1; NZ_LS483365.1.
DR RefSeq; YP_500139.1; NC_007795.1.
DR PDB; 6RJI; X-ray; 1.48 A; A=1-185.
DR PDB; 6RK3; NMR; -; A=1-185.
DR PDBsum; 6RJI; -.
DR PDBsum; 6RK3; -.
DR AlphaFoldDB; Q2FY41; -.
DR BMRB; Q2FY41; -.
DR SMR; Q2FY41; -.
DR STRING; 1280.SAXN108_1552; -.
DR EnsemblBacteria; ABD30703; ABD30703; SAOUHSC_01625.
DR GeneID; 3919963; -.
DR KEGG; sao:SAOUHSC_01625; -.
DR PATRIC; fig|93061.5.peg.1479; -.
DR eggNOG; COG0231; Bacteria.
DR HOGENOM; CLU_074944_0_1_9; -.
DR OMA; WSVVEFQ; -.
DR UniPathway; UPA00345; -.
DR PRO; PR:Q2FY41; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central.
DR CDD; cd04470; S1_EF-P_repeat_1; 1.
DR CDD; cd05794; S1_EF-P_repeat_2; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.40.50.140; -; 2.
DR HAMAP; MF_00141; EF_P; 1.
DR InterPro; IPR015365; Elong-fact-P_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR020599; Transl_elong_fac_P/YeiP.
DR InterPro; IPR013185; Transl_elong_KOW-like.
DR InterPro; IPR001059; Transl_elong_P/YeiP_cen.
DR InterPro; IPR013852; Transl_elong_P/YeiP_CS.
DR InterPro; IPR011768; Transl_elongation_fac_P.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR30053; PTHR30053; 1.
DR Pfam; PF01132; EFP; 1.
DR Pfam; PF08207; EFP_N; 1.
DR Pfam; PF09285; Elong-fact-P_C; 1.
DR PIRSF; PIRSF005901; EF-P; 1.
DR SMART; SM01185; EFP; 1.
DR SMART; SM00841; Elong-fact-P_C; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR SUPFAM; SSF50249; SSF50249; 2.
DR TIGRFAMs; TIGR00038; efp; 1.
DR PROSITE; PS01275; EFP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Elongation factor; Protein biosynthesis;
KW Reference proteome.
FT CHAIN 1..185
FT /note="Elongation factor P"
FT /id="PRO_1000010866"
FT STRAND 12..15
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 18..28
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 31..34
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 36..43
FT /evidence="ECO:0007829|PDB:6RJI"
FT TURN 44..46
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 49..54
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 60..62
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 66..76
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 79..84
FT /evidence="ECO:0007829|PDB:6RJI"
FT TURN 85..87
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 90..94
FT /evidence="ECO:0007829|PDB:6RJI"
FT TURN 95..97
FT /evidence="ECO:0007829|PDB:6RJI"
FT HELIX 101..103
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 110..116
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 119..124
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 127..135
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 149..154
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 159..163
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 171..175
FT /evidence="ECO:0007829|PDB:6RJI"
FT TURN 176..178
FT /evidence="ECO:0007829|PDB:6RJI"
FT STRAND 181..184
FT /evidence="ECO:0007829|PDB:6RJI"
SQ SEQUENCE 185 AA; 20554 MW; 9DF456C10AA64AAE CRC64;
MISVNDFKTG LTISVDNAIW KVIDFQHVKP GKGSAFVRSK LRNLRTGAIQ EKTFRAGEKV
EPAMIENRRM QYLYADGDNH VFMDNESFEQ TELSSDYLKE ELNYLKEGME VQIQTYEGET
IGVELPKTVE LTVTETEPGI KGDTATGATK SATVETGYTL NVPLFVNEGD VLIINTGDGS
YISRG
