ID   EFR3A_XENLA             Reviewed;         819 AA.
AC   Q641A2;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Protein EFR3 homolog A {ECO:0000305};
DE   AltName: Full=Protein EFR3-like;
GN   Name=efr3a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a complex required to localize
CC       phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The
CC       complex acts as a regulator of phosphatidylinositol 4-phosphate
CC       (PtdIns(4)P) synthesis. In the complex, efr3a probably acts as the
CC       membrane-anchoring component. {ECO:0000250|UniProtKB:Q14156}.
CC   -!- SUBUNIT: Component of a phosphatidylinositol 4-kinase (PI4K) complex.
CC       {ECO:0000250|UniProtKB:Q14156}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14156};
CC       Lipid-anchor {ECO:0000250|UniProtKB:Q14156}. Note=Palmitoylation
CC       anchors the protein to the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q14156}.
CC   -!- PTM: Palmitoylated at its N-terminus, anchoring the protein to the
CC       plasma membrane. {ECO:0000250|UniProtKB:Q14156}.
CC   -!- SIMILARITY: Belongs to the EFR3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC082437; AAH82437.1; -; mRNA.
DR   RefSeq; NP_001087891.1; NM_001094422.1.
DR   AlphaFoldDB; Q641A2; -.
DR   DNASU; 447752; -.
DR   GeneID; 447752; -.
DR   KEGG; xla:447752; -.
DR   CTD; 447752; -.
DR   Xenbase; XB-GENE-865807; efr3a.L.
DR   OrthoDB; 173880at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 447752; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome.
FT   CHAIN           1..819
FT                   /note="Protein EFR3 homolog A"
FT                   /id="PRO_0000270767"
FT   REGION          210..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   819 AA;  92545 MW;  0367E6FF6DBAB6AA CRC64;
     MPAGICGCCG ALRPRYKRLV DNIFPEDPRD GLVKADMEKL TFYAVSAPEK LDRIGAYLAE
     RLSRDVMRHR YGNVFIAMEA LDQLLMACHS QSIKPFVESF LHMVAKLLES GEPKLQIYGT
     NSFVKFANIE EDTPSYHRRY DFFVSRFSAM CHSCHDDPEV RKEIRIAGIR GIQGVVRKTV
     NDELRATIWE PQHMDKIVPS LLFNMQKIED TDSRTGPPAS PTTGDKEENP GILAENCFRE
     LLGRATYGNM NNAVKPVFAH LDHHKLWESN EFAVSCFKII MYSIQAQYSH HVIQQILVHL
     DLHKKDSPRI RAGIVQVLLE AVAIAAKGSI GPTVLEVFNT LLKHLTLSVD FELGDRRSSA
     GSAVFSSSST RESDERIVQN AIIQTIGFFG SNLPDYQRSE IMMFIMGKVP VFGSSPHMLD
     TSQLGDMGTK RIQIMLLRSL LMVTSGYKAK TIAAALPPAF LDPLLSPSLM EDCELRQLVL
     EILHNLIDRH DNRAKLRGIR IIPDVADLKI KREKISKQDV NFMKKHGQQL YRHIYLGCKE
     DDNVHKNYEL LYTTLALVTI ELANEEVVID LIRVAIALQD IAITNEDNLQ MFNRCGIMGM
     VAAYLNFLSQ MIAVPAFCQH VSKVIETRNM DATYFLPEVI FRDKCSLPKS LDKHEKNQIF
     LTNKIAESLG GSGYNVEKLS MPYVPQVTDE DRLSRRKSIV DTISIQVDIL SGSNTEDKVN
     TEEITFESLK KAIDNTGMEE QEKEKRRLVI EKFQKAPFEE IAAQCESKAN LLHDKLAQIL
     ELTIRPPPSP SGTLTMTAGH AQYQSVPVYE MKFPDLCVY