ID   EFR3_COCIM              Reviewed;        1288 AA.
AC   Q1E145; J3KCA6;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Protein EFR3;
GN   Name=EFR3; ORFNames=CIMG_03718;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SIMILARITY: Belongs to the EFR3 family. {ECO:0000305}.
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DR   EMBL; GG704916; EAS32694.3; -; Genomic_DNA.
DR   RefSeq; XP_001244277.1; XM_001244276.2.
DR   AlphaFoldDB; Q1E145; -.
DR   STRING; 246410.Q1E145; -.
DR   EnsemblFungi; EAS32694; EAS32694; CIMG_03718.
DR   GeneID; 4563335; -.
DR   KEGG; cim:CIMG_03718; -.
DR   VEuPathDB; FungiDB:CIMG_03718; -.
DR   InParanoid; Q1E145; -.
DR   OMA; SCRPKHQ; -.
DR   OrthoDB; 173880at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039786; EFR3.
DR   PANTHER; PTHR47766; PTHR47766; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..1288
FT                   /note="Protein EFR3"
FT                   /id="PRO_0000270775"
FT   REGION          500..522
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          816..835
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          906..964
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          980..1155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1167..1195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1208..1288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        906..927
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        992..1012
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1073..1090
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1099..1119
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1120..1139
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1168..1190
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1211..1247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1288 AA;  141333 MW;  640BE894132B1699 CRC64;
     MNSVRQSCRP KHQVLILKCY PRFQKGVQSV KPNSSELSYL LYYASTRRSK LQKVGAFLEK
     RAARDVWRGK LGNVQVTLQI LAALIEKVPR DLPLYARSIL TVLDIVLRSR EISMVEETIP
     TFELFCRHQD SATLTADHEY IIQYRELVGT YASFASTETP VTTKTPMSAP MALRWRTVGL
     KAIKSIVTSE ILSTDGAKQL NVVIPVILQN LYASGDHRLS PLQEKAKSSE RLEREQFRRR
     RMSISTVQTV DTIDGNGDPE SASGSAADAD MMAEMEARVL ALRCLEKVFS GTNRVQIRFA
     TSLVLSFIVS RRPPRTQEKQ RSANGKTDGN WATNLLEVIA NWSPVQDRFI ILVTLLETLV
     ERPLVDGQLE PQLTLASMMD WLLGSSVNLI GLSVMDVLIG LLQFVRQLLQ LGNGTQTLVP
     HHGLSTLIKP LPQMDETAAT NSQTNGENEK APTADSLRHE LLELLENCIG NLATHVYYGD
     QVSDMIRTIV IRIKPSPALE GENAHHESES DNAIQKSSPS RSDYTAESYF SSSAARITAL
     RSVKDILVVA NLRKSTSGTD PDARNRVPLH VWEGTHWLLQ DPQWEVRNAY VDAFLSWLQL
     ETKKSDLRVP TEHTRVSKMG NRRDTSDIPE RLARRIVSTA PQEENVAACH ASSFLQLLHL
     TIFDVVSESS TTESDILRLY LLLVNLVEHL GVNAARYTLP VLMKLQDTLP SSVSASKALH
     IGSLVHGYLL ALVEKFDLEG TRPAAEIINE ISKRKKRGVW LDKIQLPPRP LHHIQPSLDT
     VIEQASLPQP DKNIYSRFTS LEELVRQIES TYNSSYVSPP ISPSNSPGRS FSIPSLGLNN
     STNPHVPAGS QLPLHVKEHM LAPWSKEACL DAIEKEKAKT SSLSGSRTAT GAFAAGLNAL
     NMSAYNSGPG SPTGTAPSAS NRQDRPVSAA YAPTGNLAGF QKTRRQSIPE RRVSPAASSR
     DSTVRVNELR RVLSVINSSN VRHPSPLRGR HRVDSTVSST ESMVSDNLSF SDAGTAAADR
     PLSSRENLTA PRGLNRYHGG PNQLHGDFEP EYIPPVPPLP SSLAIPGGFP ADSRSGSSVT
     SPSHSPPRSD RPSTAPGRPA RTHSKSKGSN ASTLRQSRSL SRKKSLDTSL HERSERRATD
     LNGIPSGHSH GYSEDLGDIG IAITADTTEI APHTQDRADT SSQWSRREAS RTLSFGRRVD
     MDKLLEGLSA PNDDQQPNGT GEVSGIKIAS SGVEGSSSLT RMGKKPSFQS MNDEKKASYS
     RKTSLLSPGA APWNRLSSDR GGIGPPPY