ID   EFR3_CRYNJ              Reviewed;        1011 AA.
AC   P0CN36; Q55RT8; Q5KG92;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Protein EFR3;
GN   Name=EFR3; OrderedLocusNames=CNE04430;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- SIMILARITY: Belongs to the EFR3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW43804.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AE017345; AAW43804.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_571111.1; XM_571111.1.
DR   AlphaFoldDB; P0CN36; -.
DR   SMR; P0CN36; -.
DR   STRING; 5207.AAW43804; -.
DR   PaxDb; P0CN36; -.
DR   GeneID; 3257707; -.
DR   KEGG; cne:CNE04430; -.
DR   eggNOG; KOG1877; Eukaryota.
DR   InParanoid; P0CN36; -.
DR   OrthoDB; 173880at2759; -.
DR   Proteomes; UP000002149; Chromosome 5.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039786; EFR3.
DR   PANTHER; PTHR47766; PTHR47766; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..1011
FT                   /note="Protein EFR3"
FT                   /id="PRO_0000270776"
FT   REGION          478..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          571..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          891..927
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          955..1011
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        491..507
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..596
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        605..636
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        894..921
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        960..976
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1011 AA;  109881 MW;  A89C3863F2139ABF CRC64;
     MGCIPCRTLQ PEVAHLNACY PPPKALLTAG PEYRPLAQDL SKLTYFATNK PSKLAKIGEE
     LEKRVAQESA RASSGNHKYR ASLLISLAIL RALLTECKRD IALFARSTLR VIDSSLDVRV
     YQRGGIDLEV VGRAAAAFIA YTTYTDGSAV GVDDTLTKTY FEILRKFGSM ATVSLLDSSE
     KPDTEQQNRT RLIALAGLNG AATSDAIFAS TRDFPRQIDL IIPPLLVNTF EGQISELKLE
     SAKIGMDASP SPFFSEFAAK GPVAQRRAPS LHAHIPGEKG PTSADVVSAA LRSLHSLLQQ
     CNVTQASQII DRLVMFLDKH GWQYAERDCF VAEQVTAWIP LQYRFIVPTR LVEVLMDLQD
     RTPTPKHTSA LAMVTTILNS TTSLVGLGVT DLLQHLVSLI IRRIHFDLRD ALLPSLVQCV
     SSLGTHIYYA DQINDIVEEL ALRIAEIPSS DTARSEIIRV LTCCISGVMI MTDAADNDAE
     SKQGNNVPQP TPSTPGSPTP PNKGKLPAPA ETPFLTPLFE YLRPQAHRSS RRNPISPEVW
     QETLPLLCEA DYSVRSTYAR ALILFLETEM QRGPTPRTTP ASGGSGSETA TPNREKGVSF
     KVTEPTPGET ATQTQSGSGA TTPPKRNSRS HRPSLPLNRL QSYTHLSSFD NVATPLDFAA
     ALRILDAMHM VVPVAALVTG APMLLAVDRD AGNELVRRPG DGRAGAWVLE RKRAIRELVS
     LVWRRIADRW GIVEIDDLAN KALASLPEPY LIPPYPVPDS PPVFLSLPEE PVSFIQHTLE
     GESSSTAKPL LDQDTLLDAL VKSQTVQAAK QMDEAGLKRL FDGKWSVEQA IKDSMERFSS
     ANLRPDDDSH YNAASALLMS MNNASYQSVN GQRLSRTIDV TDLRDALGGR VDTVSTSGAP
     SIASFDDSFH SQSAPRSSLQ SRRMNKDSDV KEILKDIFKD KKKGTKAPKG IVVNRVKSAS
     ASEEARTSTG DENGLGMSGM TQGDGATGHK VVTNPPLDLS LGRPVDVSSS S