ID   EFR3_NEUCR              Reviewed;        1125 AA.
AC   Q7SHX8;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Protein efr-3;
GN   Name=efr-3; ORFNames=NCU00675;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- SIMILARITY: Belongs to the EFR3 family. {ECO:0000305}.
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DR   EMBL; CM002236; EAA36579.1; -; Genomic_DNA.
DR   RefSeq; XP_965815.1; XM_960722.2.
DR   AlphaFoldDB; Q7SHX8; -.
DR   STRING; 5141.EFNCRP00000000778; -.
DR   EnsemblFungi; EAA36579; EAA36579; NCU00675.
DR   GeneID; 3881940; -.
DR   KEGG; ncr:NCU00675; -.
DR   VEuPathDB; FungiDB:NCU00675; -.
DR   HOGENOM; CLU_003271_0_0_1; -.
DR   InParanoid; Q7SHX8; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039786; EFR3.
DR   PANTHER; PTHR47766; PTHR47766; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..1125
FT                   /note="Protein efr-3"
FT                   /id="PRO_0000270782"
FT   REGION          240..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          471..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          788..819
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          845..1093
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..489
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        845..935
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        977..1011
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1041..1083
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1125 AA;  122173 MW;  74D091425AC74C79 CRC64;
     MNALQQKCRP KHQVLVLKCY PRTIKGAVDV KPNSSELSYL LFYCQSRRAK IQKVGSFLEK
     KTASDVYHQR IGNVQVTLQI LAALIEKSPK DLPLFASCVL SILEQVLKSS DITMVESSIP
     TFQAFCENHD PTSLAADQAY FRQYVSVVQQ YASLASTRPA PGKAQHSKPI ALRWRNAGLE
     AIRSVASSDA LSSMVARQYD ILVPMILENL WTENEDFLDV LLQRVQGDNN VEDAPLLRRR
     TSNATAQPSE TTGGEPGPNP IAFLGTAVDV DKLAEEDIGV LAMQCLRQVF VAPSRSQTHN
     PTIALLRFIE ERVDQNEQVV KRDAHGKDNG WAIKVFLMAA RWAPVADRFT ILLTAIEVLT
     QRPLTDDNLR HHNTQAAMIS ALLRSDVNLI GLSVMDVLLN LLRHMQRLVQ MPGDPDSMRV
     EDETIGTDEG AIGQRRELLF RLQQCVGDLA THVYYADQIS DMIQTILLKL RPSRPTSPPN
     SSPNGERSDN GAAEDQPLES LFALTVAKIA ALKAIKAILW VASPRTKMSG GHINLSRNRV
     PIQTWDGTQW LLRDPDGLVR KAYVDAVVTW LDRETTPADS LARDESARTT LKNRAAQENN
     LARRVVSSAS ARVDKSANAP RSHFLQLLHL AIYDHALQFV DYENDLVLLH VLLAKLVSQL
     GVNAAKFGIP MIFRLQEDIQ DVETPLGKVR IGSLVHGYLW TLTEKFDCEG TAPGSAIHGE
     IIRRRSKNFW VEGINIPAPA VDLVGTPGQA RPPPQMNMRD LESEALLPFD ERASLVDCIC
     TGYQELATSP PTSPTTSPGR NFTHPMLGST LSATPKDETQ REVPAQFREL MLGDWTREAV
     LANTQAGSSQ TASLNGTNGT HRNTVNNNNR LGVNGVTSPN GSNSNLRPSS SPTGPNGVQA
     GRTRKTSIRS NGGGGSPAHS TYRAKAQQPV TSVEQLKAVL SGHLQPPPTS HGINFQHSDD
     SDDSLVSYDM APSELSFNPA ASGSRQGSPG NTSQAASSPP RRTSQDRTQQ LKFGGPLVPG
     EESVVNGAGG QEGSNGAAGN LGVPISRTTS RTQPQATTAH TTLPRPSTSS KRSIKSRAGS
     RAGPMSSSWL GEKPPAMDLA ALLKGIDSAS ISDIKSLGAG GKPPY