ID   EFTS2_TRYCC             Reviewed;         278 AA.
AC   Q4DW94;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Elongation factor Ts 2, mitochondrial;
DE            Short=EF-Ts 2 {ECO:0000255|HAMAP-Rule:MF_03135};
DE            Short=EF-TsMt 2 {ECO:0000255|HAMAP-Rule:MF_03135};
GN   ORFNames=Tc00.1047053506989.140;
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=353153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener;
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M.A., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.-N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA   da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA   Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA   Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA   Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA   Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA   Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA   Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA   Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA   Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- FUNCTION: Associates with the EF-Tu.GDP complex and induces the
CC       exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-
CC       Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
CC       {ECO:0000255|HAMAP-Rule:MF_03135}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03135}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03135}.
CC   -!- SIMILARITY: Belongs to the EF-Ts family. {ECO:0000255|HAMAP-
CC       Rule:MF_03135}.
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DR   EMBL; AAHK01000131; EAN96796.1; -; Genomic_DNA.
DR   RefSeq; XP_818647.1; XM_813554.1.
DR   AlphaFoldDB; Q4DW94; -.
DR   SMR; Q4DW94; -.
DR   STRING; 5693.XP_818647.1; -.
DR   PaxDb; Q4DW94; -.
DR   EnsemblProtists; EAN96796; EAN96796; Tc00.1047053506989.140.
DR   GeneID; 3550936; -.
DR   KEGG; tcr:506989.140; -.
DR   eggNOG; KOG1071; Eukaryota.
DR   OMA; TETVGKW; -.
DR   OrthoDB; 1048278at2759; -.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.479.20; -; 1.
DR   HAMAP; MF_00050; EF_Ts; 1.
DR   InterPro; IPR036402; EF-Ts_dimer_sf.
DR   InterPro; IPR001816; Transl_elong_EFTs/EF1B.
DR   InterPro; IPR014039; Transl_elong_EFTs/EF1B_dimer.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR11741; PTHR11741; 1.
DR   Pfam; PF00889; EF_TS; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF54713; SSF54713; 1.
PE   3: Inferred from homology;
KW   Elongation factor; Mitochondrion; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..278
FT                   /note="Elongation factor Ts 2, mitochondrial"
FT                   /id="PRO_0000402340"
SQ   SEQUENCE   278 AA;  29998 MW;  7ADD057337411F40 CRC64;
     MLCLTRLRAN VNKVAFMEMV KDLRFRTEAP IAECGAALKE THGDVEKAME VLRKKGAARA
     MKKRSRVTEH GSVVACVGGL FGAAVITVCS ETDFAARSAQ FQNTCARVKD ALQRKIIDSK
     GDVLTNPMEA HRSLVEATAE DIRSSIAVLG ENVTIKSVES LRLAPHVAEH ISIGSYTHGS
     LDVPDVGRIA GVVAVSRLDP TREVQASTLT DVARHFVASS GAEGNYAHQN FFGTEETVGQ
     WLKHHGLCFS SSLVVDFGKE PITHTASQPR NAVKHPEG