ID   AES_XENLA               Reviewed;         197 AA.
AC   O42470;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Amino-terminal enhancer of split;
DE            Short=Amino enhancer of split;
DE   AltName: Full=Protein GRG;
GN   Name=aes;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=9300818; DOI=10.1016/s0378-1119(97)00150-9;
RA   Choudhury B.K., Kim J., Kung H.-F., Li S.S.-L.;
RT   "Cloning and developmental expression of Xenopus cDNAs encoding the
RT   Enhancer of split groucho and related proteins.";
RL   Gene 195:41-48(1997).
CC   -!- FUNCTION: May act as a transcriptional corepressor. Has a possible role
CC       in the negative regulation of proteins containing WD-40 repeats. May be
CC       required for the initiation and maintenance of the differentiated state
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in brain, testis and ovary.
CC       Ubiquitously expressed in the developing embryo. Present in
CC       unfertilized and fertilized eggs.
CC   -!- DOMAIN: Lacks the C-terminal WD repeats.
CC   -!- PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family. {ECO:0000305}.
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DR   EMBL; U18776; AAC60272.1; -; mRNA.
DR   AlphaFoldDB; O42470; -.
DR   SMR; O42470; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005617; Groucho/TLE_N.
DR   InterPro; IPR009146; Groucho_enhance.
DR   PANTHER; PTHR10814; PTHR10814; 1.
DR   Pfam; PF03920; TLE_N; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Ubl conjugation.
FT   CHAIN           1..197
FT                   /note="Amino-terminal enhancer of split"
FT                   /id="PRO_0000050837"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..197
FT                   /note="CCN domain"
FT   REGION          169..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..197
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   197 AA;  22035 MW;  BA4E071A6DF40DA5 CRC64;
     MMFPQSSSRH SGSSHMPQQL KFTTSDSCDR IKDEFQLLQA QYHSLKLECD KLAGEKSEMQ
     RHYVMYYEMS YGLNIEMHKQ AEIVKRLHGI CAQVLPYLSQ EHQQQVLGAI ERAKQVTAPE
     LNSIIRQLQV HQLSQLQALA LPLTSLPMGL QAPSLPISAS SGLLSLSALG SQGHLPKEDK
     NGHEGDRRPD DDGDKSD