ID   AETX2_ANEER             Reviewed;          59 AA.
AC   P69944;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=U-actitoxin-Aer2a {ECO:0000303|PubMed:22683676};
DE            Short=U-AITX-Aer2a {ECO:0000303|PubMed:22683676};
DE   AltName: Full=AETX II {ECO:0000303|PubMed:9133656};
DE   AltName: Full=Toxin AETX-2 {ECO:0000305};
OS   Anemonia erythraea (Sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Anemonia.
OX   NCBI_TaxID=48400;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND TOXIC DOSE.
RC   STRAIN=Banda, and Moroiso; TISSUE=Nematoblast;
RX   PubMed=9133656; DOI=10.1016/s0304-4165(96)00137-7;
RA   Shiomi K., Qian W.-H., Lin X.-Y., Shimakura K., Nagashima Y., Ishida M.;
RT   "Novel polypeptide toxins with crab lethality from the sea anemone Anemonia
RT   erythraea.";
RL   Biochim. Biophys. Acta 1335:191-198(1997).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC   -!- PTM: Contains 5 disulfide bonds. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=6506; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:9133656};
CC   -!- TOXIC DOSE: LD(50) is 0.53 ug/kg to crabs.
CC       {ECO:0000269|PubMed:9133656}.
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DR   AlphaFoldDB; P69944; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Nematocyst; Secreted; Toxin.
FT   CHAIN           1..59
FT                   /note="U-actitoxin-Aer2a"
FT                   /evidence="ECO:0000269|PubMed:9133656"
FT                   /id="PRO_0000221544"
SQ   SEQUENCE   59 AA;  6512 MW;  AA94B38C46DFD3A1 CRC64;
     GEIECSSSEC CPSGKHLCKG GFVHYCCPND RYMSCGILGF GTCYCWKADY YEYGSTPTC