ID   AF1L1_DANRE             Reviewed;         746 AA.
AC   Q4V8Y7;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Actin filament-associated protein 1-like 1;
DE            Short=AFAP1-like protein 1;
GN   Name=afap1l1; ORFNames=zgc:114084;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in podosome and invadosome formation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TED9}. Cell
CC       projection, podosome {ECO:0000250|UniProtKB:Q8TED9}. Cell projection,
CC       invadopodium {ECO:0000250|UniProtKB:Q8TED9}. Cytoplasm, cytoskeleton,
CC       stress fiber {ECO:0000250|UniProtKB:Q8TED9}.
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DR   EMBL; BC097145; AAH97145.1; -; mRNA.
DR   RefSeq; NP_001025384.1; NM_001030213.1.
DR   AlphaFoldDB; Q4V8Y7; -.
DR   SMR; Q4V8Y7; -.
DR   STRING; 7955.ENSDARP00000111322; -.
DR   PaxDb; Q4V8Y7; -.
DR   GeneID; 566757; -.
DR   KEGG; dre:566757; -.
DR   CTD; 566757; -.
DR   ZFIN; ZDB-GENE-050913-76; afap1l1a.
DR   eggNOG; ENOG502R3HG; Eukaryota.
DR   InParanoid; Q4V8Y7; -.
DR   OrthoDB; 256810at2759; -.
DR   PhylomeDB; Q4V8Y7; -.
DR   PRO; PR:Q4V8Y7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0002102; C:podosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0017124; F:SH3 domain binding; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 2.
DR   InterPro; IPR030113; AFAP.
DR   InterPro; IPR030112; AFAP1L1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR14338; PTHR14338; 1.
DR   PANTHER; PTHR14338:SF1; PTHR14338:SF1; 1.
DR   Pfam; PF00169; PH; 2.
DR   SMART; SM00233; PH; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell projection; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome; Repeat.
FT   CHAIN           1..746
FT                   /note="Actin filament-associated protein 1-like 1"
FT                   /id="PRO_0000295241"
FT   DOMAIN          214..310
FT                   /note="PH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          406..497
FT                   /note="PH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          88..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          336..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          539..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          723..746
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          591..682
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        106..120
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..362
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..556
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        558..590
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   746 AA;  84166 MW;  CE906160F26C1D8E CRC64;
     MEINSKPMEL LVTELNMLLK LLDHETLSCA TEEKKMAVKN LLRQLQPSVT AKDYMYVNTS
     VYRNGTSFVE SLFETFDCDL GDLKVEMEDQ KKEPEANHTV TKPSKTDSPP PLPNTPPPED
     YYEEAVPLSP GKMPEYITSR SSSSPPNSIE DGYYEDAENN YPTTQVNGRR KNSYNDSDAL
     SSSYESYDEE EEEKGQRLTH QWPSEENSMA PVRDCHICAF LLRKKRFGQW AKQLTVIREN
     RLQCYKSSKD QSPYTDIPLS LCSVIYVPKD GRRKKHELRF TLPGGEALVL AVQSKEQAEK
     WLHVVRDVTG QGNGLDSPSS PMIPKKIELD KWCSAEKQTS DSDSMPSGES ARDIRENGKP
     KRGALSELTG TVSRAAGRKI TRIISFSKRK PPLPGDSRSS FDHDPRCGYV GVLVNRCWRE
     HWCRVRAGSL YLYQEKGEQR VPHTTVGLKG CEVVPGLGPK HPFALRILKG GAEVAALEAS
     CSEDMGRWLG VLLAETGSSA DPESLHYDYV DVETIANIRT AARHSFLWAT STGSRTYDEV
     PFETEQENER LRGRAQTKRR SSFSSSDTGK PSPQITLKRH GSNANQYGRY GKTRAQEDAR
     RYLKEKEDLE TEIDSIRTAL VALRKKKREA KEKMKSATDK QKLALEECVT KLEDSCRVKE
     GDRVDLELKL TQVKENLKKS LAGGEMEVPT ESKPAHKTQR TEAQYMESFL PVNCASEMRK
     RPPSIYASTK GNVMQKAKEW ESKKGT