ID   EFTS_CRYNJ              Reviewed;         370 AA.
AC   P0CN38; Q55VU4; Q5KKE5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Elongation factor Ts, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03135};
DE            Short=EF-Ts {ECO:0000255|HAMAP-Rule:MF_03135};
DE            Short=EF-TsMt {ECO:0000255|HAMAP-Rule:MF_03135};
DE   Flags: Precursor;
GN   Name=TSF1 {ECO:0000255|HAMAP-Rule:MF_03135}; OrderedLocusNames=CNC03280;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Associates with the EF-Tu.GDP complex and induces the
CC       exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-
CC       Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
CC       {ECO:0000255|HAMAP-Rule:MF_03135}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03135}.
CC   -!- SIMILARITY: Belongs to the EF-Ts family. {ECO:0000255|HAMAP-
CC       Rule:MF_03135}.
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DR   EMBL; AE017343; AAW42347.1; -; Genomic_DNA.
DR   RefSeq; XP_569654.1; XM_569654.1.
DR   AlphaFoldDB; P0CN38; -.
DR   SMR; P0CN38; -.
DR   STRING; 5207.AAW42347; -.
DR   PaxDb; P0CN38; -.
DR   EnsemblFungi; AAW42347; AAW42347; CNC03280.
DR   GeneID; 3256685; -.
DR   KEGG; cne:CNC03280; -.
DR   VEuPathDB; FungiDB:CNC03280; -.
DR   eggNOG; KOG1071; Eukaryota.
DR   HOGENOM; CLU_047155_4_1_1; -.
DR   InParanoid; P0CN38; -.
DR   OMA; FAKWTVG; -.
DR   OrthoDB; 1048278at2759; -.
DR   Proteomes; UP000002149; Chromosome 3.
DR   GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central.
DR   GO; GO:0070125; P:mitochondrial translational elongation; IBA:GO_Central.
DR   GO; GO:0006414; P:translational elongation; IBA:GO_Central.
DR   Gene3D; 3.30.479.20; -; 2.
DR   HAMAP; MF_00050; EF_Ts; 1.
DR   InterPro; IPR036402; EF-Ts_dimer_sf.
DR   InterPro; IPR001816; Transl_elong_EFTs/EF1B.
DR   InterPro; IPR014039; Transl_elong_EFTs/EF1B_dimer.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR11741; PTHR11741; 1.
DR   Pfam; PF00889; EF_TS; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF54713; SSF54713; 1.
PE   3: Inferred from homology;
KW   Elongation factor; Mitochondrion; Protein biosynthesis; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..29
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03135"
FT   CHAIN           30..370
FT                   /note="Elongation factor Ts, mitochondrial"
FT                   /id="PRO_0000402344"
SQ   SEQUENCE   370 AA;  39128 MW;  7D89FAF4B302C02F CRC64;
     MALLSAAPRA LRLPRRLPLG AALPALRALA TPAAAQKVPV SLIAALRKQH PVPLAQAREA
     LERSGLDLAA ALDYLRTSTS ASAEKKAAKV SGRDTNEGLI AISLLGGKRV GMIHLACETD
     FVARNQVFLD TARGVAETTA FLDVPGDHEK PQIASSPYAF DPILDFPTES LLSAPLISLP
     AADTADGSLS PLPTSEPTTI KQSLLSSLAQ TGENLKLLRA VSFAAPFPST PDVRFVPGGY
     AHGGITDKEG KVGGIVVLSV TSADPEKPIA SIIHGPGGDD LEKAAESLAR TVARQVVGFP
     TKVIDRGDRA VDDEEVLMEQ PFMMFNGDSR SVKDVLAEWG KERGVVLRVV GMRRWAVGDE
     IEIKEKETDA