ID   AF1Q_BOVIN              Reviewed;          90 AA.
AC   Q0VCT1;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein AF1q;
GN   Name=MLLT11; Synonyms=AF1Q;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cofactor for the transcription factor TCF7. Involved in
CC       regulation of lymphoid development by driving multipotent hematopoietic
CC       progenitor cells towards a T-cell fate. {ECO:0000250|UniProtKB:Q13015}.
CC   -!- SUBUNIT: Interacts with HSPA8 and LAMP2 isoform A; the interaction may
CC       target MLLT11 for degradation via chaperone-mediated autophagy.
CC       Interacts with TCF7. {ECO:0000250|UniProtKB:Q13015}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13015}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q13015}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250|UniProtKB:Q13015}.
CC       Note=Continuous nuclear export is followed by degradation.
CC       {ECO:0000250|UniProtKB:Q13015}.
CC   -!- PTM: Ubiquitinated, leading to degradation.
CC       {ECO:0000250|UniProtKB:Q13015}.
CC   -!- SIMILARITY: Belongs to the MLLT11 family. {ECO:0000305}.
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DR   EMBL; BC120019; AAI20020.1; -; mRNA.
DR   RefSeq; NP_001069637.1; NM_001076169.1.
DR   RefSeq; XP_015318247.1; XM_015462761.1.
DR   AlphaFoldDB; Q0VCT1; -.
DR   SMR; Q0VCT1; -.
DR   STRING; 9913.ENSBTAP00000020427; -.
DR   PaxDb; Q0VCT1; -.
DR   Ensembl; ENSBTAT00000020427; ENSBTAP00000020427; ENSBTAG00000015369.
DR   GeneID; 539519; -.
DR   KEGG; bta:539519; -.
DR   CTD; 10962; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015369; -.
DR   VGNC; VGNC:31502; MLLT11.
DR   eggNOG; ENOG502S7MB; Eukaryota.
DR   GeneTree; ENSGT00390000009895; -.
DR   HOGENOM; CLU_2440320_0_0_1; -.
DR   InParanoid; Q0VCT1; -.
DR   OMA; FNYWKEP; -.
DR   TreeFam; TF336906; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000015369; Expressed in Ammon's horn and 103 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0097193; P:intrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0051901; P:positive regulation of mitochondrial depolarization; ISS:UniProtKB.
DR   GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR026778; MLLT11_fam.
DR   InterPro; IPR033461; WRNPLPNID.
DR   PANTHER; PTHR15404; PTHR15404; 1.
DR   Pfam; PF15017; WRNPLPNID; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..90
FT                   /note="Protein AF1q"
FT                   /id="PRO_0000293474"
FT   MOTIF           24..32
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q13015"
FT   MOD_RES         84
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P97783"
SQ   SEQUENCE   90 AA;  10075 MW;  D9C18546B3B0EB32 CRC64;
     MRDPVSSQYS SFLFWRMPIP ELDLSELEGL GLSDTSTYKI QDSSAAKMTG KAPGAEQEKN
     PEGDALLEYS TFNFWRAPIA SIHSFELDLL