ID   AF1Q_DANRE              Reviewed;          82 AA.
AC   A3KQS5;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Protein AF1q;
GN   Name=mllt11; Synonyms=af1q; ORFNames=si:ch211-210h11.4;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Cofactor for the transcription factor TCF7. May be involved
CC       in lymphoid development. {ECO:0000250|UniProtKB:Q13015}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13015}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q13015}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250|UniProtKB:Q13015}.
CC       Note=Continuous nuclear export is followed by degradation.
CC       {ECO:0000250|UniProtKB:Q13015}.
CC   -!- PTM: Ubiquitinated, leading to degradation.
CC       {ECO:0000250|UniProtKB:Q13015}.
CC   -!- SIMILARITY: Belongs to the MLLT11 family. {ECO:0000305}.
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DR   EMBL; BX927401; CAM56382.1; -; Genomic_DNA.
DR   RefSeq; NP_001153456.1; NM_001159984.2.
DR   AlphaFoldDB; A3KQS5; -.
DR   STRING; 7955.ENSDARP00000095520; -.
DR   PaxDb; A3KQS5; -.
DR   Ensembl; ENSDART00000104750; ENSDARP00000095520; ENSDARG00000071026.
DR   GeneID; 563531; -.
DR   KEGG; dre:563531; -.
DR   CTD; 10962; -.
DR   ZFIN; ZDB-GENE-030131-3007; mllt11.
DR   eggNOG; ENOG502S7MB; Eukaryota.
DR   GeneTree; ENSGT00390000009895; -.
DR   HOGENOM; CLU_2440320_0_0_1; -.
DR   InParanoid; A3KQS5; -.
DR   OMA; FNYWKEP; -.
DR   OrthoDB; 1586302at2759; -.
DR   PhylomeDB; A3KQS5; -.
DR   TreeFam; TF336906; -.
DR   PRO; PR:A3KQS5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000071026; Expressed in muscle tissue and 22 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0097190; P:apoptotic signaling pathway; IEA:InterPro.
DR   GO; GO:0051901; P:positive regulation of mitochondrial depolarization; IBA:GO_Central.
DR   GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR026778; MLLT11_fam.
DR   InterPro; IPR033461; WRNPLPNID.
DR   PANTHER; PTHR15404; PTHR15404; 1.
DR   Pfam; PF15017; WRNPLPNID; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Ubl conjugation.
FT   CHAIN           1..82
FT                   /note="Protein AF1q"
FT                   /id="PRO_0000293475"
FT   MOTIF           24..32
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q13015"
SQ   SEQUENCE   82 AA;  9579 MW;  B03F0BDD0766F5D4 CRC64;
     MLDKTSSQFD SFLFWRQPIP SLDLSELEDL GISAPKSKEM KSTKSFPRQD EDEDRELSKF
     STFNFWKEPI PSIDTLDFSL LL