AF1Q_MOUSE
ID AF1Q_MOUSE Reviewed; 90 AA.
AC P97783;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein AF1q;
GN Name=Mllt11; Synonyms=Af1q;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RA Matsuo N., Kawamoto S., Okubo K., Matsubara K.;
RT "Cloning of mouse AF1q homologue.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Koduru P.K., Tse W., Liu J., Broome J.D.;
RT "AF1q in fetal mouse brain.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=15530661; DOI=10.1016/j.molbrainres.2004.07.022;
RA Lin H.J., Shaffer K.M., Sun Z., Jay G., He W.-W., Ma W.;
RT "AF1q, a differentially expressed gene during neuronal differentiation,
RT transforms HEK cells into neuron-like cells.";
RL Brain Res. Mol. Brain Res. 131:126-130(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Cofactor for the transcription factor TCF7. Involved in
CC regulation of lymphoid development by driving multipotent hematopoietic
CC progenitor cells towards a T-cell fate. {ECO:0000250|UniProtKB:Q13015}.
CC -!- SUBUNIT: Interacts with HSPA8 and LAMP2 isoform A; the interaction may
CC target MLLT11 for degradation via chaperone-mediated autophagy.
CC Interacts with TCF7. {ECO:0000250|UniProtKB:Q13015}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13015}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q13015}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000250|UniProtKB:Q13015}.
CC Note=Continuous nuclear export is followed by degradation.
CC {ECO:0000250|UniProtKB:Q13015}.
CC -!- TISSUE SPECIFICITY: Detected in embryonic brain cortex.
CC {ECO:0000269|PubMed:15530661}.
CC -!- INDUCTION: Up-regulated during neuronal differentiation (in vitro).
CC {ECO:0000269|PubMed:15530661}.
CC -!- PTM: Ubiquitinated, leading to degradation.
CC {ECO:0000250|UniProtKB:Q13015}.
CC -!- SIMILARITY: Belongs to the MLLT11 family. {ECO:0000305}.
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DR EMBL; AB000733; BAA19173.1; -; mRNA.
DR EMBL; U95498; AAD00803.1; -; mRNA.
DR EMBL; BC022963; AAH22963.1; -; mRNA.
DR CCDS; CCDS38544.1; -.
DR RefSeq; NP_064298.1; NM_019914.4.
DR RefSeq; XP_006501863.1; XM_006501800.3.
DR RefSeq; XP_017175158.1; XM_017319669.1.
DR RefSeq; XP_017175159.1; XM_017319670.1.
DR RefSeq; XP_017175160.1; XM_017319671.1.
DR AlphaFoldDB; P97783; -.
DR SMR; P97783; -.
DR STRING; 10090.ENSMUSP00000066448; -.
DR iPTMnet; P97783; -.
DR PhosphoSitePlus; P97783; -.
DR PaxDb; P97783; -.
DR PeptideAtlas; P97783; -.
DR PRIDE; P97783; -.
DR ProteomicsDB; 281947; -.
DR Antibodypedia; 34047; 120 antibodies from 22 providers.
DR DNASU; 56772; -.
DR Ensembl; ENSMUST00000065482; ENSMUSP00000066448; ENSMUSG00000053192.
DR Ensembl; ENSMUST00000196025; ENSMUSP00000143755; ENSMUSG00000053192.
DR Ensembl; ENSMUST00000198948; ENSMUSP00000142604; ENSMUSG00000053192.
DR GeneID; 56772; -.
DR KEGG; mmu:56772; -.
DR UCSC; uc008qit.2; mouse.
DR CTD; 10962; -.
DR MGI; MGI:1929671; Mllt11.
DR VEuPathDB; HostDB:ENSMUSG00000053192; -.
DR eggNOG; ENOG502S7MB; Eukaryota.
DR GeneTree; ENSGT00390000009895; -.
DR HOGENOM; CLU_2440320_0_0_1; -.
DR InParanoid; P97783; -.
DR OMA; FNYWKEP; -.
DR OrthoDB; 1586302at2759; -.
DR PhylomeDB; P97783; -.
DR TreeFam; TF336906; -.
DR BioGRID-ORCS; 56772; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Mllt11; mouse.
DR PRO; PR:P97783; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; P97783; protein.
DR Bgee; ENSMUSG00000053192; Expressed in embryonic brain and 273 other tissues.
DR ExpressionAtlas; P97783; baseline and differential.
DR Genevisible; P97783; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR GO; GO:0097193; P:intrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0051901; P:positive regulation of mitochondrial depolarization; ISS:UniProtKB.
DR GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR026778; MLLT11_fam.
DR InterPro; IPR033461; WRNPLPNID.
DR PANTHER; PTHR15404; PTHR15404; 1.
DR Pfam; PF15017; WRNPLPNID; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..90
FT /note="Protein AF1q"
FT /id="PRO_0000064472"
FT REGION 31..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 24..32
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250|UniProtKB:Q13015"
FT COMPBIAS 36..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 84
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 90 AA; 10029 MW; 5A8BCE378D1922F2 CRC64;
MRDPVSSQYS SFLFWRMPIP ELDLSELEGL GLSDTPTYES KDSSSVGKMN GQASGTEQKN
PEGDPLLEYS TFNFWRAPIA SIHSVDLDLL
