ID   AF1Q_PONAB              Reviewed;          90 AA.
AC   Q5R4W2;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Protein AF1q;
GN   Name=MLLT11; Synonyms=AF1Q;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cofactor for the transcription factor TCF7. Involved in
CC       regulation of lymphoid development by driving multipotent hematopoietic
CC       progenitor cells towards a T-cell fate. {ECO:0000250|UniProtKB:P97783,
CC       ECO:0000250|UniProtKB:Q13015}.
CC   -!- SUBUNIT: Interacts with HSPA8 and LAMP2 isoform A; the interaction may
CC       target MLLT11 for degradation via chaperone-mediated autophagy.
CC       Interacts with TCF7. {ECO:0000250|UniProtKB:Q13015}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13015}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q13015}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250|UniProtKB:Q13015}.
CC       Note=Continuous nuclear export is followed by degradation.
CC       {ECO:0000250|UniProtKB:Q13015}.
CC   -!- PTM: Ubiquitinated, leading to degradation.
CC       {ECO:0000250|UniProtKB:Q13015}.
CC   -!- SIMILARITY: Belongs to the MLLT11 family. {ECO:0000305}.
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DR   EMBL; CR861129; CAH93204.1; -; mRNA.
DR   RefSeq; NP_001126885.1; NM_001133413.1.
DR   AlphaFoldDB; Q5R4W2; -.
DR   SMR; Q5R4W2; -.
DR   GeneID; 100173899; -.
DR   KEGG; pon:100173899; -.
DR   CTD; 10962; -.
DR   InParanoid; Q5R4W2; -.
DR   OrthoDB; 1586302at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0097193; P:intrinsic apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0051901; P:positive regulation of mitochondrial depolarization; ISS:UniProtKB.
DR   GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR026778; MLLT11_fam.
DR   InterPro; IPR033461; WRNPLPNID.
DR   PANTHER; PTHR15404; PTHR15404; 1.
DR   Pfam; PF15017; WRNPLPNID; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..90
FT                   /note="Protein AF1q"
FT                   /id="PRO_0000064473"
FT   MOTIF           24..32
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q13015"
FT   MOD_RES         84
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P97783"
SQ   SEQUENCE   90 AA;  10075 MW;  B37C78786E683BF8 CRC64;
     MRDPVSSQYS SFLFWRMPIP ELDLSELEGL GLSDTATYKI KDSSVGKMIG QATAADQEKN
     PEGDGLLEYS TFNFWRAPIA SIHSFELDLL