ID   EFTS_LEIBR              Reviewed;         276 AA.
AC   A4HH79;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Elongation factor Ts, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03135};
DE            Short=EF-Ts {ECO:0000255|HAMAP-Rule:MF_03135};
DE            Short=EF-TsMt {ECO:0000255|HAMAP-Rule:MF_03135};
GN   ORFNames=LbrM29_V2.0730, LbrM_29_0730;
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904;
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- FUNCTION: Associates with the EF-Tu.GDP complex and induces the
CC       exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-
CC       Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
CC       {ECO:0000255|HAMAP-Rule:MF_03135}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03135}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03135}.
CC   -!- SIMILARITY: Belongs to the EF-Ts family. {ECO:0000255|HAMAP-
CC       Rule:MF_03135}.
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DR   EMBL; FR799004; CAM39929.1; -; Genomic_DNA.
DR   RefSeq; XP_001566420.1; XM_001566370.1.
DR   AlphaFoldDB; A4HH79; -.
DR   SMR; A4HH79; -.
DR   STRING; 5660.A4HH79; -.
DR   GeneID; 5417305; -.
DR   KEGG; lbz:LBRM_29_0730; -.
DR   VEuPathDB; TriTrypDB:LbrM.29.0730; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_290013500; -.
DR   InParanoid; A4HH79; -.
DR   OMA; TETVGKW; -.
DR   Proteomes; UP000007258; Chromosome 29.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.479.20; -; 1.
DR   HAMAP; MF_00050; EF_Ts; 1.
DR   InterPro; IPR036402; EF-Ts_dimer_sf.
DR   InterPro; IPR001816; Transl_elong_EFTs/EF1B.
DR   InterPro; IPR014039; Transl_elong_EFTs/EF1B_dimer.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR11741; PTHR11741; 1.
DR   Pfam; PF00889; EF_TS; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF54713; SSF54713; 1.
PE   3: Inferred from homology;
KW   Elongation factor; Mitochondrion; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..276
FT                   /note="Elongation factor Ts, mitochondrial"
FT                   /id="PRO_0000402336"
SQ   SEQUENCE   276 AA;  29864 MW;  5D8757C533BA19A6 CRC64;
     MLHRSFFRFA ALADKKAFME LVKALRYRTE APISDCSAAL TEAAGDMDAA MQLLRKRGVA
     RAMKKGDCVT EHGFVVSCVG STPASGAAII TMCSETDFAA RNEHFQRTCV QARDQLRKLM
     DATNGAVLAN PEEAAKQLSD IMGEELRAAI AVLGENMRIR SIAPLVPAPH MSERLLVGSY
     THGVLNVDGV GRIVGLVAVS QVRENEVISK DVLTSIGRHF VATSGAEGNY AHQNFFGSET
     ETVGKWLKHH GLTFSSSLVQ EFGKEPVVHT AAEPHQ