ID   AF9_CRYNB               Reviewed;         392 AA.
AC   P0CM09; Q55MP8; Q5KB23;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Protein AF-9 homolog;
GN   Name=YAF9; OrderedLocusNames=CNBH3860;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Component of the NuA4 histone acetyltransferase complex which is
CC       involved in transcriptional activation of selected genes principally by
CC       acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is
CC       also involved in DNA repair. Yaf9 may also be required for viability in
CC       conditions in which the structural integrity of the spindle is
CC       compromised (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex and of the
CC       NuA4 histone acetyltransferase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00376}.
CC   -!- DOMAIN: The coiled-coil domain is required for assembly into the NuA4
CC       complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YAF9 family. {ECO:0000305}.
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DR   EMBL; AAEY01000042; EAL19287.1; -; Genomic_DNA.
DR   RefSeq; XP_773934.1; XM_768841.1.
DR   AlphaFoldDB; P0CM09; -.
DR   SMR; P0CM09; -.
DR   EnsemblFungi; AAW45303; AAW45303; CNI04050.
DR   EnsemblFungi; EAL19287; EAL19287; CNBH3860.
DR   GeneID; 4937914; -.
DR   KEGG; cnb:CNBH3860; -.
DR   VEuPathDB; FungiDB:CNBH3860; -.
DR   HOGENOM; CLU_051385_2_1_1; -.
DR   Proteomes; UP000001435; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:InterPro.
DR   GO; GO:0000812; C:Swr1 complex; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.60.40.1970; -; 1.
DR   InterPro; IPR037989; Yaf9.
DR   InterPro; IPR038704; YEAST_sf.
DR   InterPro; IPR005033; YEATS.
DR   PANTHER; PTHR23195; PTHR23195; 1.
DR   PANTHER; PTHR23195:SF15; PTHR23195:SF15; 1.
DR   Pfam; PF03366; YEATS; 1.
DR   PROSITE; PS51037; YEATS; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Coiled coil; Cytoplasm; DNA damage;
KW   DNA repair; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..392
FT                   /note="Protein AF-9 homolog"
FT                   /id="PRO_0000410005"
FT   DOMAIN          5..268
FT                   /note="YEATS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00376"
FT   REGION          146..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          263..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          357..392
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        183..208
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        275..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   392 AA;  42549 MW;  47F10AB767537F4D CRC64;
     MSSERVRGIQ VHRPIIFGSH ARLLTEAEKQ LAPAGHTHKW TVFLNSAASP PLKQGEPPDY
     EDIDYLPGGA DDLSYFIRKV TFKLHETYAT PNRVIDKPPY RVSETGWGEF TVQIRIQLIP
     ESSEKPLGLQ HNIKLHHWGA PVEPLPVVSG APTPTPVPTE SNTEVKLEPD TPAPLEESVT
     PAPTIQRPAS EPATNEPGSN QGTPAPPGGD STEQIKVDVA TPALEVIEPS ATPAPLSLAA
     RLPIHAWQYD EIVFSDPPRQ FLDILNAHPP TPLPAKSRRP RDQREDYEAR KKGKSAARGA
     SVTASARASR AGTVDTAAAG TPAPAQIGIP GEPGSADVPL EFTQEMLKGE HNAMLDARVK
     IVEQMDRWRE RLIALEKELA KAKEDVKATA AM