ID   AF9_YARLI               Reviewed;         202 AA.
AC   Q6CF24;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Protein AF-9 homolog;
GN   Name=YAF9; OrderedLocusNames=YALI0B10912g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Component of the NuA4 histone acetyltransferase complex which is
CC       involved in transcriptional activation of selected genes principally by
CC       acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is
CC       also involved in DNA repair. Yaf9 may also be required for viability in
CC       conditions in which the structural integrity of the spindle is
CC       compromised (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex and of the
CC       NuA4 histone acetyltransferase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00376}.
CC   -!- DOMAIN: The coiled-coil domain is required for assembly into the NuA4
CC       complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YAF9 family. {ECO:0000305}.
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DR   EMBL; CR382128; CAG82984.1; -; Genomic_DNA.
DR   RefSeq; XP_500738.1; XM_500738.1.
DR   AlphaFoldDB; Q6CF24; -.
DR   SMR; Q6CF24; -.
DR   STRING; 4952.CAG82984; -.
DR   EnsemblFungi; CAG82984; CAG82984; YALI0_B10912g.
DR   GeneID; 2907040; -.
DR   KEGG; yli:YALI0B10912g; -.
DR   VEuPathDB; FungiDB:YALI0_B10912g; -.
DR   HOGENOM; CLU_051385_2_1_1; -.
DR   InParanoid; Q6CF24; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0016573; P:histone acetylation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 2.60.40.1970; -; 1.
DR   InterPro; IPR037989; Yaf9.
DR   InterPro; IPR038704; YEAST_sf.
DR   InterPro; IPR005033; YEATS.
DR   PANTHER; PTHR23195; PTHR23195; 1.
DR   PANTHER; PTHR23195:SF15; PTHR23195:SF15; 1.
DR   Pfam; PF03366; YEATS; 1.
DR   PROSITE; PS51037; YEATS; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Coiled coil; Cytoplasm; DNA damage;
KW   DNA repair; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..202
FT                   /note="Protein AF-9 homolog"
FT                   /id="PRO_0000215933"
FT   DOMAIN          1..142
FT                   /note="YEATS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00376"
FT   REGION          94..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          161..202
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   202 AA;  22826 MW;  BFDD05030BCBB5FC CRC64;
     MAAGASLKRI KEASPTPETN HELGFIKKVV FKLHDTYANS TRTIEEPPFE VTETGWGEFE
     ISIRIFFPTE MGEKNILLYH HLKLHPYKKD NIPAQIGAPG GAPNANEDEE NTNVPQPVDS
     YVYDELVFNE PSEQMFELLT SRPGALLPAK SDPNDPSKSY SLQTEAEELD RLTAGLETVY
     QQVQKTKEYI LQLEKEKETL SQ