ID   AFAGR_AGRCY             Reviewed;          15 AA.
AC   P84797;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Agrocybin;
DE   Flags: Fragment;
OS   Agrocybe cylindracea (Toadstool) (Pholiota aegerita).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Strophariaceae; Agrocybe.
OX   NCBI_TaxID=64608;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Fruiting body {ECO:0000269|PubMed:15629530};
RX   PubMed=15629530; DOI=10.1016/j.peptides.2004.09.011;
RA   Ngai P.H., Zhao Z., Ng T.B.;
RT   "Agrocybin, an antifungal peptide from the edible mushroom Agrocybe
RT   cylindracea.";
RL   Peptides 26:191-196(2005).
CC   -!- FUNCTION: Has antifungal activity against M.arachidicola with an IC(50)
CC       of 125 uM, but not against F.oxysporum. Inhibits human immunodeficiency
CC       virus-1 (HIV-1) reverse transcriptase with an IC(50) of 60 uM. Has
CC       mitogenic activity towards murine splenocytes. Lacks antiproliferative
CC       activity towards HepG2 hepatoma cells. Has antibacterial activity
CC       against the Gram-negative bacterium P.fluorescens. No antibacterial
CC       activity against the Gram-positive bacteria B.subtilis, B.cereus,
CC       B.megaterium, M.phei and S.aureus, or against the Gram-negative
CC       bacteria E.aerogenes, E.coli, P.aeruginosa, P.fluorescens and
CC       P.vulgaris. {ECO:0000269|PubMed:15629530}.
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DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide; Mitogen.
FT   CHAIN           1..>15
FT                   /note="Agrocybin"
FT                   /evidence="ECO:0000269|PubMed:15629530"
FT                   /id="PRO_0000229756"
FT   NON_TER         15
FT                   /evidence="ECO:0000303|PubMed:15629530"
SQ   SEQUENCE   15 AA;  1611 MW;  1AEDF6CD86CCEE6E CRC64;
     ANDPQCLYGN VAAKF