ID   EFTS_STRCO              Reviewed;         278 AA.
AC   O31213; O69912;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 3.
DT   25-MAY-2022, entry version 132.
DE   RecName: Full=Elongation factor Ts;
DE            Short=EF-Ts;
GN   Name=tsf; OrderedLocusNames=SCO5625; ORFNames=SC2E1.42;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=10517582; DOI=10.1099/00221287-145-9-2293;
RA   Hoogvliet G., van Wezel G.P., Kraal B.;
RT   "Evidence that a single EF-Ts suffices for the recycling of multiple and
RT   divergent EF-Tu species in Streptomyces coelicolor A3(2) and Streptomyces
RT   ramocissimus.";
RL   Microbiology 145:2293-2301(1999).
RN   [2]
RP   SEQUENCE REVISION.
RA   Hoogvliet G., van Wezel G.P., Kraal B.;
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Associates with the EF-Tu.GDP complex and induces the
CC       exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-
CC       Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EF-Ts family. {ECO:0000305}.
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DR   EMBL; AF034101; AAC00176.2; -; Genomic_DNA.
DR   EMBL; AL939124; CAA19417.1; -; Genomic_DNA.
DR   PIR; T34810; T34810.
DR   RefSeq; NP_629759.1; NC_003888.3.
DR   RefSeq; WP_003973385.1; NZ_VNID01000034.1.
DR   AlphaFoldDB; O31213; -.
DR   SMR; O31213; -.
DR   STRING; 100226.SCO5625; -.
DR   GeneID; 1101066; -.
DR   KEGG; sco:SCO5625; -.
DR   PATRIC; fig|100226.15.peg.5714; -.
DR   eggNOG; COG0264; Bacteria.
DR   HOGENOM; CLU_047155_0_0_11; -.
DR   InParanoid; O31213; -.
DR   OMA; DAGMMDC; -.
DR   PhylomeDB; O31213; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central.
DR   GO; GO:0006414; P:translational elongation; IBA:GO_Central.
DR   Gene3D; 3.30.479.20; -; 2.
DR   HAMAP; MF_00050; EF_Ts; 1.
DR   InterPro; IPR036402; EF-Ts_dimer_sf.
DR   InterPro; IPR001816; Transl_elong_EFTs/EF1B.
DR   InterPro; IPR014039; Transl_elong_EFTs/EF1B_dimer.
DR   InterPro; IPR018101; Transl_elong_Ts_CS.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR11741; PTHR11741; 1.
DR   Pfam; PF00889; EF_TS; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF54713; SSF54713; 2.
DR   TIGRFAMs; TIGR00116; tsf; 1.
DR   PROSITE; PS01126; EF_TS_1; 1.
DR   PROSITE; PS01127; EF_TS_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Elongation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..278
FT                   /note="Elongation factor Ts"
FT                   /id="PRO_0000161206"
FT   REGION          82..85
FT                   /note="Involved in Mg(2+) ion dislocation from EF-Tu"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        145
FT                   /note="A -> G (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        183..185
FT                   /note="GVA -> AR (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   278 AA;  29848 MW;  4693DAE1B845C626 CRC64;
     MANYTAADVK KLRELTGAGM MDCKKALDEA EGNVEKAVEA LRIKGQKGVA KREGRSAENG
     AVVSIIADDN TSGVLVELKC ETDFVAKGEK FQNVATAIAE HVAKAAPADL EALLASEIEP
     GKTVQAYVDE ANANLGEKIV LDRFAQFSGG FVTAYMHRTM PDLPPQIGVL VELDKPNAEI
     AKGVAQHIAA FAPKYLSKED VPAEVVESER RVAEETTRAE GKPEAALPKI VEGRLNGFFK
     DATLLGQPYA LDNKKSVQKV LEEAGVSLKR FSRIKVGI