AFF2_PANTR
ID AFF2_PANTR Reviewed; 1272 AA.
AC Q7YQM2;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=AF4/FMR2 family member 2;
GN Name=AFF2;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12777533; DOI=10.1093/molbev/msg134;
RA Kitano T., Schwarz C., Nickel B., Paeaebo S.;
RT "Gene diversity patterns at 10 X-chromosomal loci in humans and
RT chimpanzees.";
RL Mol. Biol. Evol. 20:1281-1289(2003).
CC -!- FUNCTION: RNA-binding protein. Might be involved in alternative
CC splicing regulation through an interaction with G-quartet RNA structure
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000305}.
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DR EMBL; AB102645; BAC81114.1; -; mRNA.
DR RefSeq; NP_001009042.1; NM_001009042.1.
DR AlphaFoldDB; Q7YQM2; -.
DR SMR; Q7YQM2; -.
DR STRING; 9598.ENSPTRP00000054451; -.
DR PaxDb; Q7YQM2; -.
DR PRIDE; Q7YQM2; -.
DR Ensembl; ENSPTRT00000061907; ENSPTRP00000054451; ENSPTRG00000022353.
DR GeneID; 450122; -.
DR KEGG; ptr:450122; -.
DR CTD; 2334; -.
DR VGNC; VGNC:6427; AFF2.
DR eggNOG; ENOG502QR32; Eukaryota.
DR GeneTree; ENSGT00950000182974; -.
DR InParanoid; Q7YQM2; -.
DR OrthoDB; 558558at2759; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000022353; Expressed in pituitary gland and 13 other tissues.
DR GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR GO; GO:0002151; F:G-quadruplex RNA binding; ISS:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR GO; GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; PTHR10528; 2.
DR Pfam; PF18876; AF-4_C; 1.
DR Pfam; PF18875; AF4_int; 1.
PE 2: Evidence at transcript level;
KW mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome; RNA-binding.
FT CHAIN 1..1272
FT /note="AF4/FMR2 family member 2"
FT /id="PRO_0000215914"
FT REGION 93..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..601
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..674
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 391
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P51816"
FT MOD_RES 478
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P51816"
SQ SEQUENCE 1272 AA; 140509 MW; DDF13B3E11751EE4 CRC64;
MDLFDFFRDW DLEQQCHYEQ DRSALKKREW ERRNQEVQQE DDLFSSGFDL FGEPYKTNKG
DALANRVQNT LGNYDEMKDL LTNHSNQNHL VGIPKNSVPQ NPNNKNEPSF FPEQKNRIIP
PHQDNTHPSA PMPPPSVVIL NSTLIHSNRK SKPEWSRDSH NPSTVLASQA SGQPNKMQTL
TQDQSQAKLE DFFVYPAEQP QIGEAEESNP SAKEDSNPNS SGEDAFKEIF QSNSPEESEF
AVQAPGSPLV ASSLLAPSSG LSVQNFPPGL YCKTSMGQQK PTAYVRPMDG QDQAPDISPT
LKPSIEFENS FGNLSFGTLL DGKPSAASSK TKLPKFTILQ TSEVSLPSDP SCVEEILRES
QHLTPGFTLQ KWNDPTTRAS TKMLEDDLKL SSDEDDLEPV KTLTTQCTAT ELYQAVEKAK
PRNNPVNPPL ATPQPPPAVQ ASGGSGSSSE SESSSESDSD TESSTTDSES NEAPRVATPE
PEPPSTNKWQ LDKWLNKVTS QNKSFICGQN ETPMETISLP PPIIQPMEVQ MKVKTNASQV
PAEPKERPLL SLIREKARPR PTQKIPETKA LKHKLSTTSE TVSQRTIGKK QPKKVEKNTS
IDEFTWPKPN ITSSTPKEKE SVELHDPPRG RNKATAHKPA PRKEPRPNIP LAPEKKKYRG
PGKIVPKSRE FIETDSSTSD SNTDQEETLQ IKVLPPCIIS GGNTAKSKEI CGASLTLSTL
MSSSGSNNNL SISNEEPTFS PIPVMQTEML SPLRDHENLK NLWVKIDLDL LSRVPGHNSL
HAAPAKPDHK ETATKPKRQT ALTAVEKPAP KGKRKHKPTE VAEKIPEKKQ RLEEATTICL
LPPCISPAPP HKPPNTRENN SSRRANRRKE EKLFPPPLSP LPEDPPRRRN VSGNNGPFGQ
DKNIAMTGQI TSTKPKRTEG KFCATFKGIS VNEGDTPKKA SSATITVTNT AIATATVTAT
AIVTTTVTAT ATATATTTTT TTTISTITST ITTGLMDSSH LEMTSWAALP LLSSSSTNVR
RPKLTFDDSV HNADYYMQEA KKLKHKADAL FEKFGKAVNY ADAALSFTEC GNAMERDPLE
AKSPYTMYSE TVELLRYAMR LKNFASPLAS DGDKKLAVLC YRCLSLLYLR MFKLKKDHAM
KYSRSLMEYF KQNASKVAQI PSPWVGNGKN TPSPVSLNNV SPINAMGNCN NGPVTIPQRI
HHMAASHVNI TSNVLRGYEH WDMADKLTRE NKEFFGDLDT LMGPLTQHSS MTNLVRYVRQ
GLCWLRIDAH LL
