AFFL_DROMO
ID AFFL_DROMO Reviewed; 1782 AA.
AC B4KFE1;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=AF4/FMR2 family member lilli {ECO:0000250|UniProtKB:Q9VQI9};
DE AltName: Full=Protein lilliputian {ECO:0000250|UniProtKB:Q9VQI9};
GN Name=lilli {ECO:0000250|UniProtKB:Q9VQI9}; ORFNames=GI11857;
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230;
RN [1] {ECO:0000312|EMBL:EDW12041.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000312|EMBL:EDW12041.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Has a role in transcriptional regulation. Acts in parallel
CC with the Ras/MAPK and the PI3K/PKB pathways in the control of cell
CC identity and cellular growth. Essential for regulation of the
CC cytoskeleton and cell growth but not for cell proliferation or growth
CC rate. Required specifically for the microtubule-based basal transport
CC of lipid droplets. Plays a partially redundant function downstream of
CC Raf in cell fate specification in the developing eye. Pair-rule protein
CC that regulates embryonic cellularization, gastrulation and segmentation
CC (By similarity). {ECO:0000250|UniProtKB:Q9VQI9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VQI9}.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000255}.
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DR EMBL; CH933807; EDW12041.1; -; Genomic_DNA.
DR RefSeq; XP_002002599.2; XM_002002563.2.
DR AlphaFoldDB; B4KFE1; -.
DR SMR; B4KFE1; -.
DR STRING; 7230.FBpp0161074; -.
DR KEGG; dmo:Dmoj_GI11857; -.
DR eggNOG; ENOG502QR32; Eukaryota.
DR HOGENOM; CLU_241798_0_0_1; -.
DR InParanoid; B4KFE1; -.
DR OMA; HESHNIV; -.
DR PhylomeDB; B4KFE1; -.
DR ChiTaRS; lilli; fly.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR GO; GO:0007366; P:periodic partitioning by pair rule gene; ISS:UniProtKB.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0032368; P:regulation of lipid transport; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR000637; HMGI/Y_DNA-bd_CS.
DR PANTHER; PTHR10528; PTHR10528; 1.
DR Pfam; PF18876; AF-4_C; 1.
DR PROSITE; PS00354; HMGI_Y; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Nucleus; Pair-rule protein;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1782
FT /note="AF4/FMR2 family member lilli"
FT /id="PRO_0000394676"
FT DNA_BIND 920..932
FT /note="A.T hook"
FT /evidence="ECO:0000255"
FT REGION 42..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1296..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1386..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1450..1484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1674..1701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..1011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1387..1420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1674..1700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 443
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 472
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 474
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 878
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 879
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 949
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 951
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 1457
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
SQ SEQUENCE 1782 AA; 191052 MW; 3A0FF5ECAC87E46C CRC64;
MAQQQQQQHQ QQQHHQQQQQ LLLQQQQQLL QYNNNLYNLN YNMEDNERRK RREREKYERQ
QGIQSDDRET SLFGEPRRLN PSEGDAEITA ALGEFIDARD HMNSSTVGIY RHASTNASSS
RLPALSFGGS SLANSYSTSS ASVNPAASLA SSSASVPGQL PTSQQQQQQQ QQQQHYQQQQ
RAPTYLKQAD NKPPYNGRGG YPGQPMKNDI PSSSGMAPPR GPPRSSSSAS QSNSNSNSIN
SSSATNNATS GATSASMSSP LGPPLSTQMP NGREKSFLGP PAPALPNGGR FVPPAASSKR
PSNSVGLQPP PPEKDISKII TEMTNNYRVT PLTSIAATPH APMSENYNLN GPNKFKYAFD
SIGPLNSPPA AGASSLMTPL LAPIAPITSP IAPLLTTPPQ ASQLPLPLAP LAGATTVPPA
LGGMAAVAPI QQLMPTPPKA SPTPPAIKPM KTEKNHSLEK QDSCLENDLE LSESDDERKK
EGRSAGNSSN SSESDSSESG SEASSKGDTQ QQQQQQQQQQ QQQLLLQQQQ QQQLLLQQQQ
QRLAASANGS KKKYSQTIIA SGANTISGLL TSSGLGGAGA GSVAGGAGGA GGAINATNNT
CGGGGGSSGS CMGTMSSSSS SNKTPSPTDS NRWNLSRFFP KPANQTAAES VSPGVANAIG
NVSMKVPGIL PGGAQIIPES IDVTTAIVKN EKLHDEPRHV GDDEDDEADE QHRQQQQQQQ
QQQQQQQQQQ RYGLSVTVKK EQLEQQQQQQ LLLQQQQQLT TEQLALAGAL PKNQIKRESR
LSDSGSASSG SGSGSSSSDS AGGSSEVLQM PGPGETLQIP GVPAAITTVL RVPQAMQHKV
QPNSVTLTPI GPLPASPKPR QKKPRKKKMS AATAPLDSSD EDEPTASSNK KHALELAATA
AAAAAAVAVP VAAAAAPAIK KGRGRPRKQA QQQQQQQQQQ LQQSGNLSSA SASSSQAKGP
TLTAAKKPLA KASVSNSNST APATVAAGTR KREHSSNSSS NSNTPTKKPT ATFATMAAKL
DRADALSSDD DSSSSSSCSS TKSSSSSGSD SETPAAAAAG AAASTATTVV TTSAQNPAKK
RIVKINKVGV AGNSSSSSKA KRRYSVGSSS NSSSSSETEE QQQHKQQQLL LLQQQQQKQQ
LQHQQQLQQQ QQQQQSLLGQ FAAESLPQSA QRLSSSDCSS SSNSDSSSNS SGSSSSSDED
GEHRSGKRKS DKKKICTLTR IFNPKEGGAK KQGQVVIIDQ SEEQQQQQQQ QQQQAKELKP
RATPTQLLGA TLASPARTTT PHLTSLMCKI DLSKLARQHH HQPERLKAQQ NGHLSSRSAE
GARTPKDLQQ ICTPNGYVGG AAGGGAAASK LLGGVKHEHG VKPEPELEPG YEGKYKLNSV
KQEFMLKQEL PARRRKRSSS SSSSPYKEKK RKKEKAEQLS KELLPVPVLL PANNHERLSR
DKLELLMQQQ ESAANGSPNK LQQQQQQSRL SQSQQQQQQQ QQQQSLSQST TAAATVAAAP
IQLPTTCSEA VQTTPPPAAP QPEPRLIYRS HFDKEEENEN DDLRKNDFLL QEAIRRKRAA
DSERDSFSQM TLYLEAIVYF LLTADAMERC NMEATWTMYK DTLSLIKYIS SKNRPYQLST
NGNHESHNIV AILSLRCQSL ISLKLYKLRR VNCRAIIASC TEFFRSGRGD ILNGNTPSSI
SPSNSVGSQG SGSNTPPGKI VPQDIHNMLC KQNEYLTYVN SAHELWDQAD RLVRNGNHID
FIRKLDHENG PLTLHSTMHE VFRYVQAGLK TLRDAVSYPQ SQ
