AFFL_DROPS
ID AFFL_DROPS Reviewed; 1770 AA.
AC Q29KG4;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=AF4/FMR2 family member lilli {ECO:0000250|UniProtKB:Q9VQI9};
DE AltName: Full=Protein lilliputian {ECO:0000250|UniProtKB:Q9VQI9};
GN Name=lilli {ECO:0000250|UniProtKB:Q9VQI9}; ORFNames=GA21343;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:EAL33211.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Has a role in transcriptional regulation. Acts in parallel
CC with the Ras/MAPK and the PI3K/PKB pathways in the control of cell
CC identity and cellular growth. Essential for regulation of the
CC cytoskeleton and cell growth but not for cell proliferation or growth
CC rate. Required specifically for the microtubule-based basal transport
CC of lipid droplets. Plays a partially redundant function downstream of
CC Raf in cell fate specification in the developing eye. Pair-rule protein
CC that regulates embryonic cellularization, gastrulation and segmentation
CC (By similarity). {ECO:0000250|UniProtKB:Q9VQI9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VQI9}.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000255}.
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DR EMBL; CH379061; EAL33211.2; -; Genomic_DNA.
DR AlphaFoldDB; Q29KG4; -.
DR SMR; Q29KG4; -.
DR STRING; 7237.FBpp0287399; -.
DR PRIDE; Q29KG4; -.
DR eggNOG; ENOG502QR32; Eukaryota.
DR HOGENOM; CLU_241798_0_0_1; -.
DR InParanoid; Q29KG4; -.
DR OMA; HESHNIV; -.
DR ChiTaRS; lilli; fly.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR GO; GO:0007366; P:periodic partitioning by pair rule gene; ISS:UniProtKB.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0032368; P:regulation of lipid transport; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR000637; HMGI/Y_DNA-bd_CS.
DR PANTHER; PTHR10528; PTHR10528; 1.
DR Pfam; PF18876; AF-4_C; 1.
DR PROSITE; PS00354; HMGI_Y; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Nucleus; Pair-rule protein;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1770
FT /note="AF4/FMR2 family member lilli"
FT /id="PRO_0000394677"
FT DNA_BIND 900..912
FT /note="A.T hook"
FT /evidence="ECO:0000255"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1483..1502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1656..1683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..934
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1042
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1098
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1132..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1320..1361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1368..1388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1483..1501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 470
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 472
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 863
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 864
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 920
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 922
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 1442
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
SQ SEQUENCE 1770 AA; 188886 MW; 59A03A81699B7F68 CRC64;
MAQQQQQQQQ QQHLQHPHQN TNSNNQLQQQ QQQLQLQLQL QLQEQQEQQQ QQLQLQQYNN
NFYSQNYNME EYERRKRRER EKIERQQGIQ IDDRETALFS EPRRLTEGDA EITAALGEFG
DARVYINQST VGISRHAPGA GNPRLQAPPP PKTLGHSHSP SSSSAAGSGS GSALPGQSQS
QQQQQKQHYQ QQQQQQRPPG YLKQADNKPP YNGRGGYPGQ PMKNDIPSSS GMAPPRGPPR
SGSGSISNSN SNSSSATNNA TGGAAGTTPL GPPLSTQMPN GREKSFLGPP APALHNGAGL
FVPPAASKRP GGGSGAGLQP PPPEKDITKM ISEMTNSFRV TAPLTSIAAT PHAPTRENYN
LNGPNTNKYA FGPIGSPPIG SQPSSLMAPL FAPIAPIASP ITSLLTTPPH ASQGSLGGAS
PVAPLQQLPP TPPKAAAALS PTAAAKPLKT EKNHTLEKQD SCLENDLELS ESEDEQRKKE
SRSAGNSSNS SESDSSESGS ESSSKGDHQQ QHHHHNHHHQ QQQQQLQQQQ QQQLLQQKQQ
HQQILQQQQR QLTANGSKKK YSHSIIAGGG STISGLLTSS GFGSGGAGNG GCSTASSGGG
GGGSGSGGGS GSSSGIGTMS SGSSSNKTPS PTESNKWTLS RFFPKPANQT SSESVSPGNV
SMKVPGILPG GAQIIPESIE VTTAIVKNEK IHDDHMDMDE VEEEDEDEEQ LQQQQQLRYG
AGLSVTPVAV AVKKEALDGV GEMGGLPAIP KNQIKREAEA LHSAARLSDS GTSGSGSTSS
SSSSSDSAPG EVVPMPGPGE TLQLPGVPAA ITTVMRVHPT LMQKAPPNSV TLTPILPLPA
SPKQRQKKPR KKKPATSAPI LDSSDDDDPP AAKHALELSA AAAAAAQAQA TATVPPLAVK
KGRGRPRKQQ QSGGSGNLSS ASAGSSSQTK GPTLTAAKKP LVKGPAMANS RKRDHSSQSS
SNGNTPTKKL AMGTGTGTGT AMAVPMTVIP SGPANASAVA AASSSSDEDS SSSTGSTGSK
SSSSSSSSDD TETTQNTKCR IVKLNKTGAV PPLARLGAVA SAGAGAGAGA SGSSSPSSSS
SEPEDHLAMS TVSALPMAQQ LMQPYKPRAV SQHSQQLSSS ECSSSSGSST SGDEDEAKRE
KERERKRKSD KNKISTLTRI FNPKEGGAKK QGQVVIMDQS EEQQQVKVGD SSSQPVPVQN
AAIAKLRMTP TQQQQQLGAG LASPARTTTP HLTSLICKID LSKLSRERIM RLKKLTPSQQ
NGHLTPKDLV TIQTQGPSQP VQGHLLPAKV KHEHPHPVKP EPELDAGYES KFKPGNVKQE
FQLKQERDRE RERERDRDRE RERERERDRE REREQPTGGR RRKRSSSSSS SPYKEKKRKK
EKSDHLQISK DQLLPVPVLL PSNNHERISC HERLSFDKLQ LLHEDAAAVA AAAAAVSAPN
GSPSKKLLVM SPLPPPPTAV VVPPAVVAPS TCSEAVQTTP PSAAATATAA TSTTGTSTAP
PAPVTRLIYR SYFDREEEPH SDDHRKNNQF LVEAVNRKHA ADSERDSFNQ VTLYLEAVVY
FLLTADSMER SSSEQATWTI YKDTLSLIKF ISSKFRPYQQ STNGQHETHN KVAILSLRCQ
SLISLKLYKL RRTNCRTVIN SLTEFFRTGR GDIVNGNTPS SISPSNSVGS QGSGSNTPPG
KIVPQEIHTQ LSKQNEYLTY VNSAHELWDQ ADRLVRTGNH IDFFRELDHE NGPLTLHSTM
PEVFRYVQAG LKTLRDAVSH PTQQTLHQSH
