AFFL_DROVI
ID AFFL_DROVI Reviewed; 1823 AA.
AC B4LV24;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=AF4/FMR2 family member lilli {ECO:0000250|UniProtKB:Q9VQI9};
DE AltName: Full=Protein lilliputian {ECO:0000250|UniProtKB:Q9VQI9};
GN Name=lilli {ECO:0000250|UniProtKB:Q9VQI9}; ORFNames=GJ13972;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1] {ECO:0000312|EMBL:EDW63273.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000312|EMBL:EDW63273.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Has a role in transcriptional regulation. Acts in parallel
CC with the Ras/MAPK and the PI3K/PKB pathways in the control of cell
CC identity and cellular growth. Essential for regulation of the
CC cytoskeleton and cell growth but not for cell proliferation or growth
CC rate. Required specifically for the microtubule-based basal transport
CC of lipid droplets. Plays a partially redundant function downstream of
CC Raf in cell fate specification in the developing eye. Pair-rule protein
CC that regulates embryonic cellularization, gastrulation and segmentation
CC (By similarity). {ECO:0000250|UniProtKB:Q9VQI9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VQI9}.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDW63273.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH940649; EDW63273.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_002051118.2; XM_002051082.2.
DR AlphaFoldDB; B4LV24; -.
DR SMR; B4LV24; -.
DR STRING; 7244.FBpp0228389; -.
DR PRIDE; B4LV24; -.
DR eggNOG; ENOG502QR32; Eukaryota.
DR InParanoid; B4LV24; -.
DR ChiTaRS; lilli; fly.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR GO; GO:0007366; P:periodic partitioning by pair rule gene; ISS:UniProtKB.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0032368; P:regulation of lipid transport; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR000637; HMGI/Y_DNA-bd_CS.
DR PANTHER; PTHR10528; PTHR10528; 2.
DR Pfam; PF18876; AF-4_C; 1.
DR PROSITE; PS00354; HMGI_Y; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Nucleus; Pair-rule protein;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1823
FT /note="AF4/FMR2 family member lilli"
FT /id="PRO_0000394678"
FT DNA_BIND 908..920
FT /note="A.T hook"
FT /evidence="ECO:0000255"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1071..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1480..1531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1547..1567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1715..1744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..701
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..951
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..999
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1057
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1171..1203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 434
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 463
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 465
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 859
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 860
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 939
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 941
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 1486
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
SQ SEQUENCE 1823 AA; 195478 MW; 30F75FD89415C6F2 CRC64;
MAQQQQQQHQ QQQHHQQQQQ QLQQQQQLLQ YNNNSYNLNY NMEDPERRKR REREKYERQQ
GIQSDDRETS LFGEPRRLNP NEGDPEITAA LGDFVDARDY MNASTVGIYR QAPGASNARL
QALPKGFGSA TTSFSSSSSA SASSSASVPG QLPTSQQQQQ QQQQQQQQHY QQQQRAPTYL
KQADNKPPYN GRGGYPGQPM KNDIPSSSGM APPRGPPRSS SSSSSSNNNS SSVSNNATAA
PTSASTSSPL GPPMSTQMPN GREKSFLGPP APALPNGGRF VPPSASGKRP SSTAGLQPPP
PENHINKIIT EMTNNYRVTP LTSIAATPHA PMRENYNLNG PNKFKYAFDA VDPIGPLNSP
PAAGASSLMT PLLAPIAPIT SPIAPLLTTP PQASQLPLPL PPMAGATTVP PSMAMGAVAP
MQQLTPTPPK ASPTPPVIKP LKTEKNHSLE KQDSCLENDL ELSESDDERK KDSRSAGNSS
NSSESDSSES GSEASSKGDP QQQQQQQQQH LLHQQQQHQQ QQLLLQQQQQ QRLAATANGS
KKKYSQTIIA SGANTISGLL TSSGLGGTGA GPGGAVNSTG SAAGGVGSGS GSTGGGSSSS
GMGTMSSSNS SNKTPSPTDS NRWHLSRFFP KPANQTAAES VSPGVANAMG NVSMKVPGIL
PGGAQIIPES IDVTTAIVKN EKLHDDSRHM DDDEDEQADQ QHQQQQQRYG VGLSVTVKKE
QLEQQQQQQQ QQQLLLQQQQ LTAEQLALAG ALPKNQIKRE SRLSDSGSGS SGSGSSSSDS
AGGSSEVLPM PGPGETLQIP GVPAAITTVM RVPPATQHKA QPNSVTLTPI GPLPASPKPR
QKKPRKKKMS AATAPPLDSS DEDEPANSNK KHALELAATA AAAAANAAAA SVMPVAAAAA
AAAAPAIKKG RGRPRKQAQQ QQQQLQLQQQ QQQSGNLSSA SASSSQAKGP TLTAAKKPLA
KGTASSSSSS GTAATVAAGS RKREHSSNSS SNGNTPTKKP NAAMAAAAAA AAAAAAAAIA
VRAASSSDED SSSSSCSSTK SSNSNSSSSG SDTDIPTAAP AVTTAAAVAA AAAQNPAKKR
IVKINKVGVA SSKAKRRFSL GNSSNSSSSE TEEQQQQFLQ QQQQQQQQKQ QLQQQQQQQP
QQQQLQQHHQ LQQQQQQQLL QGHFAPELPL QTLKQSAQQR LSSSDCSSSA SSDSSSNSSA
SSSSDEDDAH RSGKRKSDKK KICTLTRIFN PKEGGAKKQG QVVIIDQSEE QLQQQQQQQQ
QQQQQQQQQQ QQQQQQQQQQ AKELKPRATP TQLLGATLAS PARTTTPHLT SLMCKIDLSK
LARQHHHQPE RLKTQQNGHL SSRSAEGART PKELQQIYAP NGYVGGALGG AAGAAAGNKL
LGGVKHEHGV KPEPELDAGY EAKYKPNSVK QEFMLKQELP ARRRKRSSSS SSSPYKEKKR
KKEKAEQLSK ELLPVPVLLP ANNHERLSRD KLELLLQQQE NSANASPNKL QQQNARQLPL
SQSQLQHQHQ HQHQLQQQQS QSTATGHAIA STTSATVATA STQLPTTCSE AVQTTPPPAA
PPPAPRLIYR SHFDNEEEHA SDDHRKNDLL LQEAIRRKRA ADSERDSFNQ MTLYLEAIVY
FLLTADAMER CNMEATWTMY KDTLSLIKYI SSKNRPYQQL TNGKHESHNI VAILSLRCQS
LISLKLYKLR RANCRATIAS CSEFFRSGRG DILNGNTPSS ISPSNSVGSQ GSGSNTPPGK
IVPQDIHNQL CKQNEYLTYV NSAHELWDQA DRLVRTGNHI DFIRKLDHEN GPLTLHSTMH
EVFRYVQAGL KTLRDAVSYP QSQ
