AFFL_DROYA
ID AFFL_DROYA Reviewed; 1671 AA.
AC B4NXA8;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=AF4/FMR2 family member lilli {ECO:0000250|UniProtKB:Q9VQI9};
DE AltName: Full=Protein lilliputian {ECO:0000250|UniProtKB:Q9VQI9};
GN Name=lilli {ECO:0000250|UniProtKB:Q9VQI9}; ORFNames=GE18192;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1] {ECO:0000312|EMBL:EDW87465.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000312|EMBL:EDW87465.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Has a role in transcriptional regulation. Acts in parallel
CC with the Ras/MAPK and the PI3K/PKB pathways in the control of cell
CC identity and cellular growth. Essential for regulation of the
CC cytoskeleton and cell growth but not for cell proliferation or growth
CC rate. Required specifically for the microtubule-based basal transport
CC of lipid droplets. Plays a partially redundant function downstream of
CC Raf in cell fate specification in the developing eye. Pair-rule protein
CC that regulates embryonic cellularization, gastrulation and segmentation
CC (By similarity). {ECO:0000250|UniProtKB:Q9VQI9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VQI9}.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000255}.
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DR EMBL; CM000157; EDW87465.1; -; Genomic_DNA.
DR RefSeq; XP_002087753.1; XM_002087717.2.
DR AlphaFoldDB; B4NXA8; -.
DR SMR; B4NXA8; -.
DR STRING; 7245.FBpp0263202; -.
DR EnsemblMetazoa; FBtr0264710; FBpp0263202; FBgn0235623.
DR GeneID; 6526645; -.
DR eggNOG; ENOG502QR32; Eukaryota.
DR HOGENOM; CLU_241798_0_0_1; -.
DR OMA; HESHNIV; -.
DR PhylomeDB; B4NXA8; -.
DR ChiTaRS; lilli; fly.
DR Proteomes; UP000002282; Chromosome 2L.
DR GO; GO:0000791; C:euchromatin; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0032783; C:super elongation complex; IEA:EnsemblMetazoa.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:EnsemblMetazoa.
DR GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR GO; GO:0007611; P:learning or memory; IEA:EnsemblMetazoa.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:EnsemblMetazoa.
DR GO; GO:0007366; P:periodic partitioning by pair rule gene; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0032368; P:regulation of lipid transport; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0048190; P:wing disc dorsal/ventral pattern formation; IEA:EnsemblMetazoa.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR PANTHER; PTHR10528; PTHR10528; 1.
DR Pfam; PF18876; AF-4_C; 1.
DR PROSITE; PS00354; HMGI_Y; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Nucleus; Pair-rule protein;
KW Phosphoprotein; Transcription; Transcription regulation.
FT CHAIN 1..1671
FT /note="AF4/FMR2 family member lilli"
FT /id="PRO_0000394680"
FT DNA_BIND 849..861
FT /note="A.T hook"
FT /evidence="ECO:0000255"
FT REGION 53..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1562..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1080
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1218..1237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 416
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 446
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 448
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 819
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 820
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 869
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 871
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 1360
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
FT MOD_RES 1362
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9VQI9"
SQ SEQUENCE 1671 AA; 179779 MW; 9A37490A342B69BD CRC64;
MAQQQQQQLQ QQQQHHTSSI NNNNSILLLH QQQPQQQQQQ QLDQLQQYNN NLYSQNYNME
EYERRKRRER EKIERQQGIQ IDDRETSLFG EPRRLTEGDA EITAALGEFF EARVYINNQT
VGISRSAPGA GNPRLQPNLP PQAKSLGHSP SSASSAAGPT SASATTALPG QQQHYQQQQR
PPTYVKQADN KPPYNGRGGY PGQPMKNDIP SSSGMAPPRG PPRSSSSNSN SSSATNNASS
GGVPANTPLG PPLSTQMPNG REKSFLGPPA PALHNGTGGG RFVPPAASKR PGVGQQPPPP
EKDVNKIISD IANIFSVQPL TSIAATPHAP TRENYNLLAP NKQKYAMDIP SSPPSAEPSS
LMTPLFTPIA PLVTTPPQAS QLPLGAATSG TILAGEPLAP LHQLPPTPPK AASGVTSPGP
TKPLKTEKNH SLEKQDSCLE NDLELSESED EQRKKEGRSA GNSSNSSESD SSESGSESSS
KNDLQHHPNH QQHHHQLQQQ QQASMQQQQV LQQQQQHRPQ PLTSNGAQNK KFRHEIIARG
SNTITGLLSS SGFGSGGSVG PAGVNSSAVM GAGSVSGGTL SSGGSSSNKT PSPTESNKWN
LSRFFHKPAN QTNSESVSPG NVSMKVPGIL PGGAQIIPES IDVTTAIVKN EKIHDDHMAM
EEGEEEDDDE EQQMRYGGGL SVTPVAVKKE AIDAVSEMAL GAIPKTQIKR ESAEALLSAR
LSDSGTSASG SSSSSSSSSD SAVGGEVVPM PGPGETFQLP GVPADITTVV RVPPTQSQKA
PPSNSVTLTP ILPLPTSPKQ RQKKPRKKKA VTSAPILDSS DDDEPPPKHP GLDHSAVSVQ
AQPATDTVKK GRGRPRKQQQ SGGSGNLSSA SAGSSSQTKG PTLTAAKKPL AKTPLAMSRA
RKREHSSQSS SNGNTPTKKV ATPVLVAAPL KPTSVTAGSS SSDEDSSSSA ESSSKSSSSS
SSSDDTETQN TNCRIVKLNK TGAVQKKALL GSGSSSASSS GSEPEDQTSR SQVGSGQALA
QQLPPYKQLP ISQHSQHLSS SECSSSSGGC TAVCSSSSGE EDEGRREKER ERKPKSDKNK
ISTLTRIFNP KEGGAKKQGQ VVIVDLQEEQ QQGKLDAAAQ PPPPHAPPAA PAAIMAKPRM
TPTQQQQLGA GLASPARTTT PHLTSLICKI DLSKLSRERI MRLKKLTPAQ QNGHLTPKDQ
ATNAVHVPNG YAGDTNPAAK VKHEHPVKPE PELDAGYEAK FKPGNVKQEF QLKQERDRDR
ERERERERER ERDREREQPP GRRRKRSSSS SSSPYKEKKR KKEKADQLQI GKELLPVPVL
LPSNNHERMP NHDRLSYDKL QLLHEDAAAV IGDVSAANGS PTKKLLVMSP LPPPPTVTVA
PATCNEAVQT TPPSATTTTA TAPPVPATRL IYRSYFDRDV EHPSDDLRKN NQFLQEAINR
KHAADLERDS FNQVTLYLEA VVYFLLTADA MERCSSEQAT NTMYKDTLSL IKFISTKFRP
YQQQSTTNIQ HETHNKVAIL SLRCQSLISL KLYKLRRKDC RAIINGLTDF FRVGRGDIAN
GNTPSSISPS NSVGSQGSGS NTPPGRIVSP DIHNMLCKQN EFLSYLNSAH ELWDQADRLV
RTGNHIDFIR ELDHENGPLT LHSTMHEVFR YVQAGLKTLR DAVSHPTHQS Q
