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EFTU_GLOVI
ID   EFTU_GLOVI              Reviewed;         409 AA.
AC   P50064;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2003, sequence version 2.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Elongation factor Tu {ECO:0000255|HAMAP-Rule:MF_00118};
DE            Short=EF-Tu {ECO:0000255|HAMAP-Rule:MF_00118};
GN   Name=tufA {ECO:0000255|HAMAP-Rule:MF_00118}; OrderedLocusNames=glr3928;
OS   Gloeobacter violaceus (strain ATCC 29082 / PCC 7421).
OC   Bacteria; Cyanobacteria; Gloeobacteria; Gloeobacterales; Gloeobacteraceae;
OC   Gloeobacter.
OX   NCBI_TaxID=251221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29082 / PCC 7421;
RX   PubMed=14621292; DOI=10.1093/dnares/10.4.137;
RA   Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T.,
RA   Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M.,
RA   Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of Gloeobacter violaceus PCC 7421, a
RT   cyanobacterium that lacks thylakoids.";
RL   DNA Res. 10:137-145(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-324.
RC   STRAIN=ATCC 29082 / PCC 7421;
RX   PubMed=7663757; DOI=10.1006/mpev.1995.1012;
RA   Delwiche C.F., Kuhsel M., Palmer J.D.;
RT   "Phylogenetic analysis of tufA sequences indicates a cyanobacterial origin
RT   of all plastids.";
RL   Mol. Phylogenet. Evol. 4:110-128(1995).
CC   -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC       tRNA to the A-site of ribosomes during protein biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00118}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00118}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00118}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00118}.
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DR   EMBL; BA000045; BAC91869.1; -; Genomic_DNA.
DR   EMBL; U09433; AAA87693.1; -; Genomic_DNA.
DR   RefSeq; NP_926874.1; NC_005125.1.
DR   RefSeq; WP_011143916.1; NC_005125.1.
DR   AlphaFoldDB; P50064; -.
DR   SMR; P50064; -.
DR   STRING; 251221.35214501; -.
DR   PRIDE; P50064; -.
DR   EnsemblBacteria; BAC91869; BAC91869; BAC91869.
DR   KEGG; gvi:glr3928; -.
DR   PATRIC; fig|251221.4.peg.3961; -.
DR   eggNOG; COG0050; Bacteria.
DR   HOGENOM; CLU_007265_0_1_3; -.
DR   InParanoid; P50064; -.
DR   OMA; EGDKEWG; -.
DR   OrthoDB; 621774at2; -.
DR   PhylomeDB; P50064; -.
DR   Proteomes; UP000000557; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central.
DR   GO; GO:0006414; P:translational elongation; IBA:GO_Central.
DR   CDD; cd01884; EF_Tu; 1.
DR   CDD; cd03697; EFTU_II; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00118_B; EF_Tu_B; 1.
DR   InterPro; IPR041709; EF-Tu_GTP-bd.
DR   InterPro; IPR004161; EFTu-like_2.
DR   InterPro; IPR033720; EFTU_2.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR   InterPro; IPR004541; Transl_elong_EFTu/EF1A_bac/org.
DR   InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   Pfam; PF03143; GTP_EFTU_D3; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF50465; SSF50465; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00485; EF-Tu; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Elongation factor; GTP-binding; Nucleotide-binding;
KW   Protein biosynthesis; Reference proteome.
FT   CHAIN           1..409
FT                   /note="Elongation factor Tu"
FT                   /id="PRO_0000091330"
FT   DOMAIN          10..214
FT                   /note="tr-type G"
FT   REGION          19..26
FT                   /note="G1"
FT                   /evidence="ECO:0000250"
FT   REGION          60..64
FT                   /note="G2"
FT                   /evidence="ECO:0000250"
FT   REGION          81..84
FT                   /note="G3"
FT                   /evidence="ECO:0000250"
FT   REGION          136..139
FT                   /note="G4"
FT                   /evidence="ECO:0000250"
FT   REGION          174..176
FT                   /note="G5"
FT                   /evidence="ECO:0000250"
FT   BINDING         19..26
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00118"
FT   BINDING         81..85
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00118"
FT   BINDING         136..139
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00118"
FT   CONFLICT        158
FT                   /note="Missing (in Ref. 2; AAA87693)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        228..233
FT                   /note="VFSITG -> LLVSR (in Ref. 2; AAA87693)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        240
FT                   /note="Missing (in Ref. 2; AAA87693)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        260..264
FT                   /note="GTRST -> TRS (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        274
FT                   /note="Missing (in Ref. 2; AAA87693)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   409 AA;  44760 MW;  D1290EEA0D4D3CB7 CRC64;
     MARAKFERNK PHVNIGTIGH VDHGKTTLTA AITMTLAALG RAKAKKYDEI DQAPEEKARG
     ITINTAHVEY ETEKRHYAHV DCPGHADYVK NMITGAAQMD GAILVVSAAD GPMPQTREHI
     LLARQVGVPN IVVFLNKKDQ LDDPELLELV ELEVRELLSK YDFPGDDVPI VAGSALMALE
     KMASEPKLIR GKDDWVDCIY SLMDAVDAYI PTPERAIDKP FLMAVEDVFS ITGRGTVATG
     RIERGKVKVG ETIELVGIRG TRSTTVTGLE MFQKSLDEGL AGDNIGVLLR GIKKEDVERG
     MVLAKPGSIT PHTQFEGEVY ILSKEEGGRH TPFFAGYRPQ FYVRTTDVTG TIVTFTDDEG
     KSAEMVMPGD RIKMTVELIN PIAIEDGMRF AIREGGRTVG AGVVSKILK
 
 
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