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AFLJ_DOTSN
ID   AFLJ_DOTSN              Reviewed;         456 AA.
AC   M2YJ20;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2013, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Dothistromin biosynthesis regulatory protein aflJ {ECO:0000303|PubMed:23207690};
GN   Name=aflJ {ECO:0000303|PubMed:23207690}; ORFNames=DOTSEDRAFT_57214;
OS   Dothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight
OS   fungus) (Mycosphaerella pini).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Dothistroma.
OX   NCBI_TaxID=675120;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NZE10 / CBS 128990;
RX   PubMed=23209441; DOI=10.1371/journal.pgen.1003088;
RA   de Wit P.J.G.M., van der Burgt A., Oekmen B., Stergiopoulos I.,
RA   Abd-Elsalam K.A., Aerts A.L., Bahkali A.H., Beenen H.G., Chettri P.,
RA   Cox M.P., Datema E., de Vries R.P., Dhillon B., Ganley A.R.,
RA   Griffiths S.A., Guo Y., Hamelin R.C., Henrissat B., Kabir M.S.,
RA   Jashni M.K., Kema G., Klaubauf S., Lapidus A., Levasseur A., Lindquist E.,
RA   Mehrabi R., Ohm R.A., Owen T.J., Salamov A., Schwelm A., Schijlen E.,
RA   Sun H., van den Burg H.A., van Ham R.C.H.J., Zhang S., Goodwin S.B.,
RA   Grigoriev I.V., Collemare J., Bradshaw R.E.;
RT   "The genomes of the fungal plant pathogens Cladosporium fulvum and
RT   Dothistroma septosporum reveal adaptation to different hosts and lifestyles
RT   but also signatures of common ancestry.";
RL   PLoS Genet. 8:E1003088-E1003088(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NZE10 / CBS 128990;
RX   PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA   Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA   Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA   LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA   Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA   Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA   Grigoriev I.V.;
RT   "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT   genomes of eighteen Dothideomycetes fungi.";
RL   PLoS Pathog. 8:E1003037-E1003037(2012).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=23207690; DOI=10.1016/j.fgb.2012.11.006;
RA   Chettri P., Ehrlich K.C., Cary J.W., Collemare J., Cox M.P.,
RA   Griffiths S.A., Olson M.A., de Wit P.J., Bradshaw R.E.;
RT   "Dothistromin genes at multiple separate loci are regulated by AflR.";
RL   Fungal Genet. Biol. 51:12-20(2013).
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25986547; DOI=10.1016/j.funbio.2015.01.007;
RA   Chettri P., Ehrlich K.C., Bradshaw R.E.;
RT   "Regulation of the aflatoxin-like toxin dothistromin by AflJ.";
RL   Fungal Biol. 119:503-508(2015).
CC   -!- FUNCTION: Transcription coactivator involved in regulation of the
CC       dothistromin biosynthesis gene cluster with aflR (PubMed:25986547).
CC       {ECO:0000269|PubMed:25986547}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: Expression is 8-fold up regulated when aflR is deleted
CC       (PubMed:23207690). {ECO:0000269|PubMed:23207690}.
CC   -!- DISRUPTION PHENOTYPE: Strongly reduces the expression of dothistromin
CC       biosynthesis genes such as hexA, hexB, pksA, adhA, vbsA, dotB, ver1 and
CC       dotB, and the subsequent production of dothistromin (PubMed:25986547).
CC       {ECO:0000269|PubMed:25986547}.
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DR   EMBL; KB446546; EME38896.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2YJ20; -.
DR   SMR; M2YJ20; -.
DR   EnsemblFungi; EME38896; EME38896; DOTSEDRAFT_57214.
DR   eggNOG; KOG3178; Eukaryota.
DR   HOGENOM; CLU_005533_11_0_1; -.
DR   OMA; LLACIQW; -.
DR   OrthoDB; 817726at2759; -.
DR   Proteomes; UP000016933; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..456
FT                   /note="Dothistromin biosynthesis regulatory protein aflJ"
FT                   /id="PRO_0000443471"
FT   DOMAIN          74..143
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DNA_BIND        104..123
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   REGION          289..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   456 AA;  49795 MW;  DE667FB017D1DE7B CRC64;
     MSRISRLGAC AEELAIAATT IAAFCKHHSN SGLPGDSIPP DAPQKVLQAK QSVITNSQKL
     EVLLAEPADF IQRLARENQL LACLQWLGEF QVLACIPIVD SVHYSDVADL ACVPVDQLRR
     IARMTITAGF LQEPKPGYVA HSGLSAPFVK QPVLLDAAMF LSETLAPSAL HMSLATKRHG
     RTHQTDQCAF NTAFNTKASF ADSLGRRPRL QRQWPSFSRY AIADDEAGVE DVMTRLDWLS
     LGEATVVDVC AKTASLATAL TSKYPSLRFV VQSEEQCQNH TWSRSLSATK LHNGLSTPPE
     SDTGPAARAA KASERLELQQ RALGSPQNVT NAAVYILRLG TASPFTSWHK LRAQATAELS
     AHADILRKEH GSRLILVTRT LPKPGEVETT VEAMARFRDL TLMQLANVRE LETSEVVELL
     NSVHIEGGCL VLTNELRTRN SGMIAFEATY QPQLLG
 
 
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