ID   AFN_CALVI               Reviewed;          13 AA.
AC   P83412;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   02-JUN-2021, entry version 39.
DE   RecName: Full=Alloferon-1;
DE   Contains:
DE     RecName: Full=Alloferon-2;
OS   Calliphora vicina (Blue blowfly) (Calliphora erythrocephala).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Calliphoridae; Calliphorinae; Calliphora.
OX   NCBI_TaxID=7373 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, INDUCTION, MASS SPECTROMETRY, AND SYNTHESIS.
RC   TISSUE=Hemolymph;
RX   PubMed=12235362; DOI=10.1073/pnas.192301899;
RA   Chernysh S., Kim S.I., Bekker G., Pleskach V.A., Filatova N.A.,
RA   Anikin V.B., Platonov V.G., Bulet P.;
RT   "Antiviral and antitumor peptides from insects.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:12628-12632(2002).
CC   -!- FUNCTION: Antimicrobial peptide presumably with antiparasitic,
CC       antiviral and/or antitumoral activities. {ECO:0000269|PubMed:12235362}.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:12235362}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12235362}.
CC   -!- TISSUE SPECIFICITY: Hemolymph. {ECO:0000269|PubMed:12235362}.
CC   -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:12235362}.
CC   -!- MASS SPECTROMETRY: [Alloferon-1]: Mass=1265.15; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:12235362};
CC   -!- MASS SPECTROMETRY: [Alloferon-2]: Mass=1128.63; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:12235362};
CC   -!- MISCELLANEOUS: Stimulates antiviral and antitumoral resistance when
CC       injected in mice. Enhances natural cytotoxicity of blood and spleen
CC       lymphocytes. Induces interferon production in mouse and human.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antiviral protein; Direct protein sequencing; Immunity; Innate immunity;
KW   Secreted.
FT   PEPTIDE         1..13
FT                   /note="Alloferon-1"
FT                   /id="PRO_0000020637"
FT   PEPTIDE         2..13
FT                   /note="Alloferon-2"
FT                   /id="PRO_0000020638"
SQ   SEQUENCE   13 AA;  1265 MW;  E7AC6F11B19ED871 CRC64;
     HGVSGHGQHG VHG