ID   AFP1_PASED              Reviewed;          25 AA.
AC   P84884;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Antifungal protein 1;
DE   AltName: Full=Pf-AFP1;
DE   Flags: Fragment;
OS   Passiflora edulis (Passion fruit).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Passifloraceae; Passiflora.
OX   NCBI_TaxID=78168;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Seed {ECO:0000269|PubMed:16766236};
RX   PubMed=16766236; DOI=10.1016/j.bbapap.2006.04.010;
RA   Pelegrini P.B., Noronha E.F., Muniz M.A.R., Vasconcelos I.M.,
RA   Chiarello M.D., Oliveira J.T., Franco O.L.;
RT   "An antifungal peptide from passion fruit (Passiflora edulis) seeds with
RT   similarities to 2S albumin proteins.";
RL   Biochim. Biophys. Acta 1764:1141-1146(2006).
CC   -!- FUNCTION: Has strong antifungal activity against T.harzianum,
CC       F.oxysporum and A.fumigatus with IC(50) values of 32 ug/ml, 34 ug/ml
CC       and 40 ug/ml, restectively. Lacks antifungal activity against R.solani,
CC       P.brasiliensis and C.albicans. {ECO:0000269|PubMed:16766236}.
CC   -!- TISSUE SPECIFICITY: Expressed in seed (at protein level). Not detected
CC       in pulp, stems and leaves. {ECO:0000269|PubMed:16766236}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in dormant seed.
CC       {ECO:0000269|PubMed:16766236}.
CC   -!- SIMILARITY: Belongs to the 2S seed storage albumins family.
CC       {ECO:0000269|PubMed:16766236}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P84884; -.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antimicrobial; Direct protein sequencing; Fungicide; Plant defense.
FT   CHAIN           1..>25
FT                   /note="Antifungal protein 1"
FT                   /id="PRO_0000247742"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         25
FT                   /evidence="ECO:0000303|PubMed:16766236"
SQ   SEQUENCE   25 AA;  3000 MW;  D20F43FC55E65B37 CRC64;
     QSERFEQQMQ GQDFSHDERF LSQAA