ID   EFUF_HORCR              Reviewed;         493 AA.
AC   A0A2Z4HQ22;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2018, sequence version 1.
DT   23-FEB-2022, entry version 10.
DE   RecName: Full=MFS-type transporter efuF {ECO:0000303|PubMed:30051576};
DE   AltName: Full=Enfumafungin biosynthesis cluster protein F {ECO:0000303|PubMed:30051576};
GN   Name=efuF {ECO:0000303|PubMed:30051576};
OS   Hormonema carpetanum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Dothideales; Dothioraceae; Hormonema.
OX   NCBI_TaxID=284138;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=30051576; DOI=10.1111/1462-2920.14333;
RA   Kuhnert E., Li Y., Lan N., Yue Q., Chen L., Cox R.J., An Z., Yokoyama K.,
RA   Bills G.F.;
RT   "Enfumafungin synthase represents a novel lineage of fungal triterpene
RT   cyclases.";
RL   Environ. Microbiol. 20:3325-3342(2018).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of enfumafungin, a glycosylated fernene-type
CC       triterpenoid with potent antifungal activity, mediated by its
CC       interaction with beta-1,3-glucan synthase and the fungal cell wall
CC       (PubMed:30051576). Might facilitate the transport of glucose units to
CC       the subcellular site of enfumafungin biosynthesis (Probable).
CC       {ECO:0000269|PubMed:30051576, ECO:0000305|PubMed:30051576}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; MF611887; AWW17215.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..493
FT                   /note="MFS-type transporter efuF"
FT                   /id="PRO_0000454463"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   493 AA;  53856 MW;  915D58562B9159BD CRC64;
     MATSVEADTK SQVNLKVAND GGESASETGV VDVYDDPLIH NSIRKKLDLK LLPLLSAMYL
     FNAIDRSNLG NAKTDGLEKD LHMKGNEYSI TLVLFYVTFC LLDVPANMLL KKFSGKIMLP
     TLMMGWGSMT LIQCAVHNWG GLIACRLLMG AFEAGFMAGV VYYLTTFYRR NELALRISIF
     YGAATIAGAF SGLLAYGVFQ INHPSIPGWK FLMIIEGSAT ILLASFAYWH LPSSVLSCKW
     FTEEEKHVAE QRMLHDGSIQ TDEKFALKTA LANLLDWKIA LYAVIGISYG VASASVGNFL
     PQMVQRLGFG TVKTNLYTVA PYCVGCVILL AQCTSSDHFR ERSTHLAGAM LLTFVGFILL
     ITLDTEAQPG PTYFACFLLA AGAFTPSCIF HSWHNNNTPS ENGRAAVTGF MVGASNSGGI
     ISSLAFASKT APKYIPALIV TATFQGVGIV LVLGFGAWFR WDNRRRDRVQ GVRIRTGDVA
     TVSVDDASWR WTA