ID   EFUK_HORCR              Reviewed;         696 AA.
AC   A0A2Z4HQ03;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2018, sequence version 1.
DT   03-AUG-2022, entry version 12.
DE   RecName: Full=Probable transporter efuK {ECO:0000303|PubMed:30051576};
DE   AltName: Full=Enfumafungin biosynthesis cluster protein K {ECO:0000303|PubMed:30051576};
GN   Name=efuK {ECO:0000303|PubMed:30051576};
OS   Hormonema carpetanum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Dothideales; Dothioraceae; Hormonema.
OX   NCBI_TaxID=284138;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=30051576; DOI=10.1111/1462-2920.14333;
RA   Kuhnert E., Li Y., Lan N., Yue Q., Chen L., Cox R.J., An Z., Yokoyama K.,
RA   Bills G.F.;
RT   "Enfumafungin synthase represents a novel lineage of fungal triterpene
RT   cyclases.";
RL   Environ. Microbiol. 20:3325-3342(2018).
CC   -!- FUNCTION: Probable transporter; part of the gene cluster that mediates
CC       the biosynthesis of enfumafungin, a glycosylated fernene-type
CC       triterpenoid with potent antifungal activity, mediated by its
CC       interaction with beta-1,3-glucan synthase and the fungal cell wall
CC       (PubMed:30051576). Might be involved in transport of enfumafungin to
CC       and across organelle membranes (Probable).
CC       {ECO:0000269|PubMed:30051576, ECO:0000305|PubMed:30051576}.
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR   EMBL; MF611893; AWW17221.1; -; Genomic_DNA.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF12697; Abhydrolase_6; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS01013; OSBP; 1.
PE   3: Inferred from homology;
KW   Transport.
FT   CHAIN           1..696
FT                   /note="Probable transporter efuK"
FT                   /id="PRO_0000454465"
FT   REGION          603..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        620..634
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   696 AA;  78433 MW;  650ED925822A00D5 CRC64;
     MTIHSPWETS HSKKGLIDIG THRLFARVSG PRRKPGDPVI LIECGGGSIS LLWTGVMRAL
     SPTYRIFTYS RAGLEGSDLP PNRGPRTAVE MADDFEKLLD VAGIKSPYII VGHSYAGVQI
     RTWMHVHDRM EDIVGAVFVD TATEYTYPRM PIREPQFWFL MEQIPNPAHV LGYDRVHKFF
     NKEQWEEVLS TDLGHEEKDV DASAAQLKTW KQFERQIMED KPVSVIKGYF AEDLRRLCVE
     AERIGAGTPA QRQYVMENLD SLDRVFEETE TEQLRLSSCA RMVHAAPGSG HTIVFSDPEI
     VMNEIKWVVE QYEAKRSIAT IKGDLSNITA PPFLLASQST CEFPSYWAEH PSIFVAPALE
     PDPKKRALLV LRWFLAALKR QQYAGRDEKE GVKKPLNAFL GELFFAQWQD QSGTTKLVSE
     QVSHHPPITA CYLWNDEHGV RADGFACQSI TFSGTVNIKQ MGHAILHIDK YDEDYLIPLP
     NVKVQGLLTG TPYPELVGSY QIACSSGFVA DIDFSGKKLF GMSGTKNMLH AALYSADDKQ
     RENPIYTIEG AWNDKFTIRD ESTGENVETY DTAANPATIL EVAPLDLQDP WESRKAWGET
     ISSLNGGKMQ GASDAKSKVE QGQRAMRKQD EQNGSKWEPV FFSNEPRDER YIRLTAVAGT
     STEEHSQSGF WKFDKDRAER ARKPYHGSLR PDNVES