ID   EG15A_MDBVW             Reviewed;         343 AA.
AC   Q4ZJZ3;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   23-FEB-2022, entry version 36.
DE   RecName: Full=Protease inhibitor Egf1.5a;
DE   Flags: Precursor;
GN   Name=O1;
OS   Microplitis demolitor bracovirus (isolate Webb) (MdBV).
OC   Viruses; Polydnaviridae; Bracovirus.
OX   NCBI_TaxID=654919;
OH   NCBI_TaxID=69319; Microplitis demolitor.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16380146; DOI=10.1016/j.virol.2005.11.010;
RA   Webb B.A., Strand M.R., Dickey S.E., Beck M.H., Hilgarth R.S., Barney W.E.,
RA   Kadash K., Kroemer J.A., Lindstrom K.G., Rattanadechakul W., Shelby K.S.,
RA   Thoetkiattikul H., Turnbull M.W., Witherell R.A.;
RT   "Polydnavirus genomes reflect their dual roles as mutualists and
RT   pathogens.";
RL   Virology 347:160-174(2006).
RN   [2]
RP   FUNCTION, AND INTERACTION WITH PAP1; PAP3 AND SPH2.
RX   PubMed=20417280; DOI=10.1016/j.ibmb.2010.04.009;
RA   Lu Z., Beck M.H., Strand M.R.;
RT   "Egf1.5 is a second phenoloxidase cascade inhibitor encoded by Microplitis
RT   demolitor bracovirus.";
RL   Insect Biochem. Mol. Biol. 40:497-505(2010).
CC   -!- FUNCTION: Counteracts the host humoral immune response by inhibiting
CC       the processing and the amidolytic activity of host PAP1 and PAP3.
CC       Thereby, melanization of host hemolymph, normally producing several
CC       reactive intermediates toxic for viruses, is deregulated and proper
CC       immune response cannot occur. {ECO:0000269|PubMed:20417280}.
CC   -!- SUBUNIT: Interacts with host PAP1, PAP3 and SPH2.
CC       {ECO:0000269|PubMed:20417280}.
CC   -!- SIMILARITY: Belongs to the polydnaviridae EGF-like motif protein
CC       family. {ECO:0000305}.
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DR   EMBL; DQ000240; AAY24525.1; -; Genomic_DNA.
DR   RefSeq; YP_239416.1; NC_007044.1.
DR   GeneID; 3416068; -.
DR   KEGG; vg:3416068; -.
DR   Proteomes; UP000008168; Genome.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   SUPFAM; SSF57567; SSF57567; 1.
PE   1: Evidence at protein level;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Reference proteome; Signal; Viral immunoevasion.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..343
FT                   /note="Protease inhibitor Egf1.5a"
FT                   /id="PRO_0000405389"
FT   DOMAIN          52..104
FT                   /note="TIL"
SQ   SEQUENCE   343 AA;  39394 MW;  1DC73EE2B880A10A CRC64;
     MYIDTGIMSN NIFLFAFFAL VGLTRIEAMP TKGSEGTWDV DYEDQEHTGI TCRENEHYNS
     TRIECEDECN DRNNKLCYRF QQFCWCNEGY IRNSSHICVK LEDCLKDEEQ KSETLASSAN
     NDSSKRLEDD LKLFSHDSVS HTSLEPETQA QKFNGIINEE TLDLVFGKPE NSWAENKPLE
     TKTQAQKFNG IINEETLDLV FGKPENSWAE NKPLETETQA QKFNGIINEE TLDLVFGKPE
     NSWAENKPLE TKTQAQKFNG IINEETLDLV FGKPENSWAE NKPLETKTQA QKFNGIINEE
     TLDLVFGKPE NSWAENKPLE TKTQTQKFNG IIDQYTRSIV FVF