ID   EG15B_MDBVW             Reviewed;         346 AA.
AC   Q4ZJZ1;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   23-FEB-2022, entry version 34.
DE   RecName: Full=Protease inhibitor Egf1.5b;
DE   Flags: Precursor;
GN   Name=O5;
OS   Microplitis demolitor bracovirus (isolate Webb) (MdBV).
OC   Viruses; Polydnaviridae; Bracovirus.
OX   NCBI_TaxID=654919;
OH   NCBI_TaxID=69319; Microplitis demolitor.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16380146; DOI=10.1016/j.virol.2005.11.010;
RA   Webb B.A., Strand M.R., Dickey S.E., Beck M.H., Hilgarth R.S., Barney W.E.,
RA   Kadash K., Kroemer J.A., Lindstrom K.G., Rattanadechakul W., Shelby K.S.,
RA   Thoetkiattikul H., Turnbull M.W., Witherell R.A.;
RT   "Polydnavirus genomes reflect their dual roles as mutualists and
RT   pathogens.";
RL   Virology 347:160-174(2006).
CC   -!- FUNCTION: Counteracts the host humoral immune response by inhibiting
CC       the processing and the amidolytic activity of host PAP1 and PAP3.
CC       Thereby, melanization of host hemolymph, normally producing several
CC       reactive intermediates toxic for viruses, is deregulated and proper
CC       immune response cannot occur (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host PAP1, PAP3 and SPH2. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the polydnaviridae EGF-like motif protein
CC       family. {ECO:0000305}.
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DR   EMBL; DQ000240; AAY24527.1; -; Genomic_DNA.
DR   RefSeq; YP_239418.1; NC_007044.1.
DR   GeneID; 3416070; -.
DR   KEGG; vg:3416070; -.
DR   Proteomes; UP000008168; Genome.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   SUPFAM; SSF57567; SSF57567; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Reference proteome; Signal; Viral immunoevasion.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..346
FT                   /note="Protease inhibitor Egf1.5b"
FT                   /id="PRO_0000405390"
FT   DOMAIN          52..104
FT                   /note="TIL"
SQ   SEQUENCE   346 AA;  39663 MW;  2EED793128F04779 CRC64;
     MYIDTGIMSN NIFLFAFFAL VGLTRIEAMP TKGSEGTWNV DYEDQEHTGI TCRENEHYNS
     TRIECEDECN DRNNKLCYRF QQFCWCNEGY IRNSSHICVK LEDCLKDEEQ KSETLASSAN
     NDSSKRLEDD LKLFSHDSVS HTSLEPETQA QKFNGIIDQE TLDLVFGKPE NSSADNKPLE
     TKTQAQKFNG IINEETLDLV FGKPENSWAE NKPLETKTQA QKFNGIINEE TLDLVFGKPE
     NSWAENKPLE TETQAQKFNG IINEETLDLV FGKPENSWAE NKPLETKTQA QKFNGIINEE
     TLDLVFGKPE NSWAENKPLE TKTQTQKFNG IIDQYTRRIV FVFSNI