EGC2_ARATH
ID EGC2_ARATH Reviewed; 130 AA.
AC Q9ZV52;
DT 03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2002, sequence version 2.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=EG45-like domain containing protein 2;
DE AltName: Full=Plant natriuretic peptide A;
DE Short=AtEXPR3;
DE Short=AtPNP-A;
DE Short=Ath-ExpGamma-1.2;
DE Flags: Precursor;
GN Name=EGC2; Synonyms=EXPR3, PNP-A; OrderedLocusNames=At2g18660;
GN ORFNames=MSF3.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND FUNCTION.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=11965432; DOI=10.1007/s00239-001-0055-4;
RA Ludidi N.N., Heazlewood J.L., Seoighe C., Irving H.R., Gehring C.A.;
RT "Expansin-like molecules: novel functions derived from common domains.";
RL J. Mol. Evol. 54:587-594(2002).
RN [5]
RP FUNCTION.
RX PubMed=14706834; DOI=10.1016/s0014-5793(03)01384-x;
RA Morse M., Pironcheva G., Gehring C.;
RT "AtPNP-A is a systemically mobile natriuretic peptide immunoanalogue with a
RT role in Arabidopsis thaliana cell volume regulation.";
RL FEBS Lett. 556:99-103(2004).
CC -!- FUNCTION: Plays a systemic role in water and solute homeostasis.
CC {ECO:0000269|PubMed:11965432, ECO:0000269|PubMed:14706834}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in unstressed leaves.
CC {ECO:0000269|PubMed:11965432}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD08935.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC005724; AAD08935.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002685; AEC06790.1; -; Genomic_DNA.
DR EMBL; AY065269; AAL38745.1; -; mRNA.
DR EMBL; AY142603; AAN13172.1; -; mRNA.
DR PIR; A84567; A84567.
DR RefSeq; NP_849979.1; NM_179648.2.
DR AlphaFoldDB; Q9ZV52; -.
DR SMR; Q9ZV52; -.
DR STRING; 3702.AT2G18660.1; -.
DR SwissPalm; Q9ZV52; -.
DR PaxDb; Q9ZV52; -.
DR PRIDE; Q9ZV52; -.
DR ProteomicsDB; 221924; -.
DR EnsemblPlants; AT2G18660.1; AT2G18660.1; AT2G18660.
DR GeneID; 816381; -.
DR Gramene; AT2G18660.1; AT2G18660.1; AT2G18660.
DR KEGG; ath:AT2G18660; -.
DR Araport; AT2G18660; -.
DR TAIR; locus:2053983; AT2G18660.
DR eggNOG; ENOG502S1DA; Eukaryota.
DR HOGENOM; CLU_112218_2_1_1; -.
DR InParanoid; Q9ZV52; -.
DR OMA; YTRSACY; -.
DR OrthoDB; 1540699at2759; -.
DR PhylomeDB; Q9ZV52; -.
DR PRO; PR:Q9ZV52; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZV52; baseline and differential.
DR Genevisible; Q9ZV52; AT.
DR GO; GO:0048046; C:apoplast; IDA:TAIR.
DR GO; GO:0051428; F:peptide hormone receptor binding; IPI:TAIR.
DR GO; GO:0010230; P:alternative respiration; IDA:TAIR.
DR GO; GO:0009627; P:systemic acquired resistance; IEP:TAIR.
DR Gene3D; 2.40.40.10; -; 1.
DR InterPro; IPR044206; EGC1/2.
DR InterPro; IPR007112; Expansin/allergen_DPBB_dom.
DR InterPro; IPR009009; RlpA-like_DPBB.
DR InterPro; IPR036908; RlpA-like_sf.
DR PANTHER; PTHR47295; PTHR47295; 1.
DR Pfam; PF03330; DPBB_1; 1.
DR SUPFAM; SSF50685; SSF50685; 1.
DR PROSITE; PS50842; EXPANSIN_EG45; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..130
FT /note="EG45-like domain containing protein 2"
FT /id="PRO_0000008717"
FT DOMAIN 28..130
FT /note="Expansin-like EG45"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 130
FT /note="Missing (in Ref. 1; AAD08935)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 130 AA; 14518 MW; B0C51C6065043BC9 CRC64;
MIKMAVKFVV VMIVFAQILA PIAEAAQGKA VYYDPPYTRS ACYGTQRETL VVGVKNNLWQ
NGRACGRRYR VRCIGATYNF DRACTGRTVD VKVVDFCREP CNGDLNLSRD AFRVIANTDA
GNIRVVYTPI
