ID   EGFL8_PIG               Reviewed;         295 AA.
AC   A5A8Y8;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Epidermal growth factor-like protein 8;
DE            Short=EGF-like protein 8;
DE   Flags: Precursor;
GN   Name=EGFL8;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The pig genome sequencing consortium;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; AL773562; CAN13271.1; -; Genomic_DNA.
DR   RefSeq; NP_001116583.1; NM_001123111.1.
DR   AlphaFoldDB; A5A8Y8; -.
DR   STRING; 9823.ENSSSCP00000001540; -.
DR   PaxDb; A5A8Y8; -.
DR   Ensembl; ENSSSCT00000001582; ENSSSCP00000001540; ENSSSCG00000001434.
DR   Ensembl; ENSSSCT00015108589; ENSSSCP00015046075; ENSSSCG00015079914.
DR   Ensembl; ENSSSCT00025079401; ENSSSCP00025034468; ENSSSCG00025057995.
DR   Ensembl; ENSSSCT00030068490; ENSSSCP00030031291; ENSSSCG00030049076.
DR   Ensembl; ENSSSCT00035081292; ENSSSCP00035033607; ENSSSCG00035060571.
DR   Ensembl; ENSSSCT00040071342; ENSSSCP00040030434; ENSSSCG00040052768.
DR   Ensembl; ENSSSCT00045063802; ENSSSCP00045045025; ENSSSCG00045036962.
DR   Ensembl; ENSSSCT00050024649; ENSSSCP00050010311; ENSSSCG00050018157.
DR   Ensembl; ENSSSCT00065042003; ENSSSCP00065017811; ENSSSCG00065031047.
DR   Ensembl; ENSSSCT00070045115; ENSSSCP00070038012; ENSSSCG00070022692.
DR   GeneID; 100144521; -.
DR   KEGG; ssc:100144521; -.
DR   CTD; 80864; -.
DR   VGNC; VGNC:87585; EGFL8.
DR   eggNOG; KOG1217; Eukaryota.
DR   GeneTree; ENSGT00940000162975; -.
DR   HOGENOM; CLU_083642_0_0_1; -.
DR   InParanoid; A5A8Y8; -.
DR   OMA; LGTCSCE; -.
DR   OrthoDB; 749722at2759; -.
DR   TreeFam; TF331360; -.
DR   Proteomes; UP000008227; Chromosome 7.
DR   Proteomes; UP000314985; Chromosome 7.
DR   Bgee; ENSSSCG00000001434; Expressed in blood and 44 other tissues.
DR   ExpressionAtlas; A5A8Y8; baseline and differential.
DR   Genevisible; A5A8Y8; SS.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR011489; EMI_domain.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF07546; EMI; 1.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00179; EGF_CA; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS51041; EMI; 1.
PE   3: Inferred from homology;
KW   Calcium; Coiled coil; Disulfide bond; EGF-like domain; Glycoprotein;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..295
FT                   /note="Epidermal growth factor-like protein 8"
FT                   /id="PRO_0000294929"
FT   DOMAIN          34..112
FT                   /note="EMI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00384"
FT   DOMAIN          111..143
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          145..185
FT                   /note="EGF-like 2; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   COILED          202..233
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        50
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        38..97
FT                   /evidence="ECO:0000255"
FT   DISULFID        65..71
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..110
FT                   /evidence="ECO:0000255"
FT   DISULFID        115..125
FT                   /evidence="ECO:0000250"
FT   DISULFID        119..131
FT                   /evidence="ECO:0000250"
FT   DISULFID        133..142
FT                   /evidence="ECO:0000250"
FT   DISULFID        149..160
FT                   /evidence="ECO:0000250"
FT   DISULFID        156..169
FT                   /evidence="ECO:0000250"
FT   DISULFID        171..184
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   295 AA;  32402 MW;  CE232FE3E5714640 CRC64;
     MGSRAELHTL LGGLSFLLLL MSGQGAKGGS FKESQGVCSR QTLVVPLRYN ESYSQPVYKP
     YLTLCPGRRV CSTYRTTYRV AWREVRREVQ QTHAVCCQGW KKRHPGALTC DEAICAKPCQ
     NGGVCVRPDQ CECAPGWGGR HCHVDVDECR TGVTLCSHRC HNTAGSFTCG CPHGLVLGPD
     GRTCAEGASE PPTSASILSV AVREAGREDR ALRREIRELR GRLERLEQWA GQAGAWVRAV
     LPMPPEELQP EQVAELWGRG DRIESLSDQV LLLEEKLGAC SCEDNSLGPG LSRRR