EGFL8_RAT
ID EGFL8_RAT Reviewed; 291 AA.
AC Q6MG84; A0JPK1;
DT 25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Epidermal growth factor-like protein 8;
DE Short=EGF-like protein 8;
DE Flags: Precursor;
GN Name=Egfl8; Synonyms=Ng3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15060004; DOI=10.1101/gr.1987704;
RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT "The genomic sequence and comparative analysis of the rat major
RT histocompatibility complex.";
RL Genome Res. 14:631-639(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6MG84-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6MG84-2; Sequence=VSP_026673;
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DR EMBL; BX883044; CAE83962.1; -; Genomic_DNA.
DR EMBL; BC127463; AAI27464.1; -; mRNA.
DR RefSeq; NP_001004070.1; NM_001004070.2. [Q6MG84-1]
DR RefSeq; NP_001159352.1; NM_001165880.1. [Q6MG84-2]
DR RefSeq; XP_006256040.1; XM_006255978.3. [Q6MG84-1]
DR RefSeq; XP_006256041.1; XM_006255979.3. [Q6MG84-1]
DR RefSeq; XP_017457200.1; XM_017601711.1. [Q6MG84-1]
DR RefSeq; XP_017457201.1; XM_017601712.1. [Q6MG84-1]
DR AlphaFoldDB; Q6MG84; -.
DR STRING; 10116.ENSRNOP00000000499; -.
DR GlyGen; Q6MG84; 1 site.
DR PaxDb; Q6MG84; -.
DR Ensembl; ENSRNOT00000000499; ENSRNOP00000000499; ENSRNOG00000000436. [Q6MG84-1]
DR Ensembl; ENSRNOT00000068712; ENSRNOP00000063796; ENSRNOG00000000436. [Q6MG84-2]
DR GeneID; 406166; -.
DR KEGG; rno:406166; -.
DR UCSC; RGD:1549706; rat. [Q6MG84-1]
DR CTD; 80864; -.
DR RGD; 1549706; Egfl8.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000162975; -.
DR HOGENOM; CLU_083642_0_0_1; -.
DR InParanoid; Q6MG84; -.
DR OMA; LGTCSCE; -.
DR OrthoDB; 749722at2759; -.
DR PhylomeDB; Q6MG84; -.
DR PRO; PR:Q6MG84; -.
DR Proteomes; UP000002494; Chromosome 20.
DR Bgee; ENSRNOG00000000436; Expressed in thymus and 19 other tissues.
DR Genevisible; Q6MG84; RN.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07546; EMI; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 1.
DR SUPFAM; SSF57184; SSF57184; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51041; EMI; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Coiled coil; Disulfide bond;
KW EGF-like domain; Glycoprotein; Reference proteome; Repeat; Secreted;
KW Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..291
FT /note="Epidermal growth factor-like protein 8"
FT /id="PRO_0000007533"
FT DOMAIN 33..111
FT /note="EMI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00384"
FT DOMAIN 110..141
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 143..183
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT COILED 198..231
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 37..96
FT /evidence="ECO:0000250"
FT DISULFID 64..70
FT /evidence="ECO:0000250"
FT DISULFID 95..109
FT /evidence="ECO:0000250"
FT DISULFID 113..123
FT /evidence="ECO:0000250"
FT DISULFID 117..129
FT /evidence="ECO:0000250"
FT DISULFID 131..140
FT /evidence="ECO:0000250"
FT DISULFID 147..158
FT /evidence="ECO:0000250"
FT DISULFID 154..167
FT /evidence="ECO:0000250"
FT DISULFID 169..182
FT /evidence="ECO:0000250"
FT VAR_SEQ 279..291
FT /note="SCEDNSLGPGLHG -> ESPAPPP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026673"
SQ SEQUENCE 291 AA; 31667 MW; FF4D326339ABC730 CRC64;
MEPWAGCCIF LRGFSFLLVL MTEGAKGGPF KESLGVCSKQ TLLVPLRYNE SYSQPVYRPY
LTLCAGRRIC STYRTTYRVA WREVRREVQQ THVVCCQGWK KPHPGALTCE AICSKPCLNG
GVCAGPDQCE CASGWAGKHC HVDVDECRTS LTLCSHGCLN TLGSFTCSCP NPLVLGPDGR
ACAGGPPESS TSAGILSVAV READSEEHAL RREVAELRGR LERLEQWATQ AGAWVRAVLP
VAPEDLRPEQ VAELWGRGDR IESLSDQVLL LEERLGACSC EDNSLGPGLH G
