ID   AFP4_GADMO              Reviewed;         125 AA.
AC   Q56TU0;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Type-4 ice-structuring protein;
DE   AltName: Full=Antifreeze protein type IV;
DE   Flags: Precursor;
OS   Gadus morhua (Atlantic cod).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Gadus.
OX   NCBI_TaxID=8049;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RA   Goetz F.W., Norberg B., Duman J.;
RT   "A cod antifreeze protein.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Antifreeze proteins lower the blood freezing point.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC       {ECO:0000305}.
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DR   EMBL; AY584595; AAT95404.1; -; mRNA.
DR   AlphaFoldDB; Q56TU0; -.
DR   SMR; Q56TU0; -.
DR   STRING; 8049.ENSGMOP00000002623; -.
DR   Ensembl; ENSGMOT00000035463; ENSGMOP00000040258; ENSGMOG00000031648.
DR   GeneTree; ENSGT00760000119766; -.
DR   Proteomes; UP000694546; Chromosome 22.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Antifreeze protein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..125
FT                   /note="Type-4 ice-structuring protein"
FT                   /id="PRO_0000042948"
SQ   SEQUENCE   125 AA;  13991 MW;  4ED7D330E8D66FF8 CRC64;
     MKYTLIAAIV VLALAQGTLA VEQSPELEKM AQFFEGMKTE LMATVQKVSE SLQSQTIIED
     GRTQLEPIMT QIQEHLAPLA TSVQEKVTPL AEDMQQKLKP YVDEFQSELE SVLRKLLDQA
     KAITQ