EGG6_CAEEL
ID EGG6_CAEEL Reviewed; 961 AA.
AC P90920;
DT 29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Leucine-rich repeat-containing protein egg-6;
DE Flags: Precursor;
GN Name=egg-6 {ECO:0000312|EMBL:CAB03182.1, ECO:0000312|WormBase:K07A12.2};
GN ORFNames=K07A12.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AEZ55700.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RC STRAIN=Bristol N2 {ECO:0000269|PubMed:22278925};
RX PubMed=22278925; DOI=10.1242/dev.075135;
RA Mancuso V.P., Parry J.M., Storer L., Poggioli C., Nguyen K.C., Hall D.H.,
RA Sundaram M.V.;
RT "Extracellular leucine-rich repeat proteins are required to organize the
RT apical extracellular matrix and maintain epithelial junction integrity in
RT C. elegans.";
RL Development 139:979-990(2012).
RN [2] {ECO:0000312|EMBL:CAB03182.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:CAB03182.1};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required for apical extracellular matrix organization and
CC epithelial junction maintenance. {ECO:0000269|PubMed:22278925}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000269|PubMed:22278925}; Single-pass type I membrane protein
CC {ECO:0000255, ECO:0000269|PubMed:22278925}.
CC -!- TISSUE SPECIFICITY: In L1 larvae, expressed in a subset of epithelial
CC cells including epidermal, vulval and rectal cells and the excretory
CC duct and pore. Also detected in some neurons. Absent from internal
CC epithelia such as the gut and pharyngeal tubes.
CC {ECO:0000269|PubMed:22278925}.
CC -!- DEVELOPMENTAL STAGE: Expression begins around the ventral closure stage
CC of embryogenesis, continues throughout larval development and decreases
CC in adulthood. {ECO:0000269|PubMed:22278925}.
CC -!- DISRUPTION PHENOTYPE: Lethal at early L1 larval stage due to excretory
CC defects. Maternal copy required for survival.
CC {ECO:0000269|PubMed:22278925}.
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DR EMBL; JQ292908; AEZ55700.1; -; mRNA.
DR EMBL; Z81098; CAB03182.1; -; Genomic_DNA.
DR PIR; T23395; T23395.
DR RefSeq; NP_492348.1; NM_059947.5.
DR AlphaFoldDB; P90920; -.
DR SMR; P90920; -.
DR BioGRID; 38103; 1.
DR DIP; DIP-24762N; -.
DR STRING; 6239.K07A12.2; -.
DR EPD; P90920; -.
DR PaxDb; P90920; -.
DR PeptideAtlas; P90920; -.
DR EnsemblMetazoa; K07A12.2.1; K07A12.2.1; WBGene00010621.
DR GeneID; 172670; -.
DR KEGG; cel:CELE_K07A12.2; -.
DR UCSC; K07A12.2; c. elegans.
DR CTD; 172670; -.
DR WormBase; K07A12.2; CE11866; WBGene00010621; egg-6.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000159318; -.
DR HOGENOM; CLU_308015_0_0_1; -.
DR InParanoid; P90920; -.
DR OMA; AFMNVPQ; -.
DR OrthoDB; 189363at2759; -.
DR PhylomeDB; P90920; -.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR SignaLink; P90920; -.
DR PRO; PR:P90920; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00010621; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 12.
DR PROSITE; PS51450; LRR; 14.
PE 2: Evidence at transcript level;
KW Cell membrane; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..961
FT /note="Leucine-rich repeat-containing protein egg-6"
FT /evidence="ECO:0000255"
FT /id="PRO_0000422394"
FT TOPO_DOM 19..854
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 855..875
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 876..961
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 60..78
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 79..101
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 103..124
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 125..148
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 150..172
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 174..197
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 199..222
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 223..245
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 247..269
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 270..294
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 305..316
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 317..339
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 340..363
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 364..387
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 388..411
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 413..435
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 437..455
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REGION 890..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 961 AA; 105365 MW; 486ABFEA9A5AAF4B CRC64;
MRWLTLIAVA HLIAFLSSAE ITCPRIPEKC DCKISKSMII LSCNGEDVKT IAQTVGTSQI
DELHILNGTD VKIESLPFNG LRTIAILNST LQSFSPTAWR HVEATIEHIT INGNELKTVP
VFGNLSTLMS MNLNSNQISS IPDKAFNGLS ALTQLRLENN AICDFPPKSL DAVKASLVLL
DVSGNCLDAI PAQILRNAAN LMYLDLGSNN ISEINNFELM NLPFLRELRV QNNTLRRIHP
MAFMNVPQLQ YLYLQDNIIS TLDGNRLQGF KNLEVLDVSN NALYALPSLK DLPNLKQVRV
DGNLITKIET LAFSNNPNLQ LISVQNNNIV QISRNSFESL DKLVVLLVGN NSLAKIERGM
FDGMKNLQQL SIRNNTLTAL DASSFAQLAH LTTLDLGHNK IHDIEEGTFD KLSKLFWLDL
SNNKISGFKT SVFKKKISNI LLDGNQLICD ESFNEFLTYL IANKVRTFLP FQQEIMCHGP
EKYAGVRLKD LMMKKANETL SEGSRLLGVP QGSNQHSLLS SFLPSLGPLG TLNGAGGAAI
PLVNTLTNTI PALRSIPGFG GNIPVGTGAS SVPNKNLNDA IEGFTGPLVR FATGGQPVAS
DIEQLIRSIP NMVVNVPGFG DIDLSKMDPT MIQYVLNGGQ IPGIDKATLD KIVKQTMNKM
HTAAAANLAG NPVEGQEKVL PPLDKLPSGL VTQVMSGEPL PGLNENQTKI IMEYYTHQMP
GMDGIPARPV ESQGNTTANN MFNPAMFDLL KMLPPGYNLS KIPMEVIAAV TRGEVPDMRL
LPEDLLEHFK QHTTSLTSMF AGATAKNISI EEILEKLPVF VRPELSTFVP YDINELTSEM
VLEQEQNERH RNIRIITAIA LAFVGAVTVV VIIFFVNYTK KQRRLRKSLV YRSSPSSSGS
SGQNAANESG RSSAAPSPIR PPLMNIPKTP NNRTMESTFG QPQLCSTLLE NPQAVSHRSR
H
