ID   AFP4_PAROL              Reviewed;         124 AA.
AC   Q8JI37;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Type-4 ice-structuring protein;
DE   AltName: Full=Antifreeze protein type IV;
DE   Flags: Precursor;
OS   Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Paralichthyidae;
OC   Paralichthys.
OX   NCBI_TaxID=8255;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Lee J., Song Y.;
RT   "Antifreeze protein gene of Japanese flounder similar to antifreeze protein
RT   type IV of Longhorn sculpin.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Antifreeze proteins lower the blood freezing point.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC       {ECO:0000305}.
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DR   EMBL; AF384676; AAM46175.1; -; Genomic_DNA.
DR   RefSeq; XP_019957605.1; XM_020102046.1.
DR   AlphaFoldDB; Q8JI37; -.
DR   SMR; Q8JI37; -.
DR   GeneID; 109638865; -.
DR   KEGG; pov:109638865; -.
DR   OrthoDB; 1382930at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Antifreeze protein; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..124
FT                   /note="Type-4 ice-structuring protein"
FT                   /id="PRO_0000042949"
FT   MOD_RES         21
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   124 AA;  13946 MW;  EA84868080E761F5 CRC64;
     MKFSLIAAVA LLALAQGSFA QDAADLEKIT QYFENLKNKM TEDVTAFLTN QDVANQAQTF
     MQERKTQLEP LATQIQEQLR AAATKFEEHI TPLAANVQPV VENFQQQMEA LVQKLMEKTR
     SISN