ID   AFP_CENMR               Reviewed;          10 AA.
AC   B3EWI7;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2012, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Antifungal peptide {ECO:0000303|PubMed:22210491};
DE   AltName: Full=Cm-p1 {ECO:0000303|PubMed:22210491};
DE   Flags: Fragment;
OS   Cenchritis muricatus (Beaded periwinkle).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Littorinimorpha; Littorinoidea; Littorinidae; Cenchritis.
OX   NCBI_TaxID=197001;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RX   PubMed=22210491; DOI=10.1016/j.biochi.2011.12.016;
RA   Lopez-Abarrategui C., Alba A., Silva O.N., Reyes-Acosta O.,
RA   Vasconcelos I.M., Oliveira J.T., Migliolo L., Costa M.P., Costa C.R.,
RA   Silva M.R., Garay H.E., Dias S.C., Franco O.L., Otero-Gonzalez A.J.;
RT   "Functional characterization of a synthetic hydrophilic antifungal peptide
RT   derived from the marine snail Cenchritis muricatus.";
RL   Biochimie 94:968-974(2012).
CC   -!- FUNCTION: The synthetic peptide has antifungal activity against
CC       B.cinerea (MIC=20 uM), F.oxysporum (MIC=20 uM), A.niger (MIC=41 uM),
CC       C.albicans strain 01U (MIC=13 uM), C.albicans strain 38U (MIC=7 uM),
CC       C.parapsilosis (MIC=105 uM), C.neoformans strain L26 (MIC=209 uM),
CC       C.neoformans strain L30 (MIC=209 uM) and T.rubrum (MIC=3 uM). Has no
CC       antibacterial or cytotoxic activity. {ECO:0000269|PubMed:22210491}.
CC   -!- MASS SPECTROMETRY: Mass=1485.26; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:22210491};
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DR   PDB; 2MP9; NMR; -; A=1-10.
DR   PDB; 6CTG; NMR; -; A=1-10.
DR   PDBsum; 2MP9; -.
DR   PDBsum; 6CTG; -.
DR   BMRB; B3EWI7; -.
DR   SMR; B3EWI7; -.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Antimicrobial; Direct protein sequencing; Fungicide.
FT   PEPTIDE         1..10
FT                   /note="Antifungal peptide"
FT                   /evidence="ECO:0000269|PubMed:22210491"
FT                   /id="PRO_0000417917"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|PubMed:22210491"
FT   NON_TER         10
FT                   /evidence="ECO:0000303|PubMed:22210491"
FT   HELIX           3..10
FT                   /evidence="ECO:0007829|PDB:2MP9"
SQ   SEQUENCE   10 AA;  1224 MW;  9CCA0EF2C0572B05 CRC64;
     SRSELIVHQR