EGO2_YEAST
ID EGO2_YEAST Reviewed; 75 AA.
AC Q3E830; D6VR78;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Protein EGO2;
GN Name=EGO2 {ECO:0000312|SGD:S000028519};
GN OrderedLocusNames=YCR075W-A {ECO:0000312|SGD:S000028519};
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1574125; DOI=10.1038/357038a0;
RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA Sgouros J.G.;
RT "The complete DNA sequence of yeast chromosome III.";
RL Nature 357:38-46(1992).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP GENOME REANNOTATION.
RX PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA Gates K., Gaffney T.D., Philippsen P.;
RT "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT comparison to the genome of a related fungus: Ashbya gossypii.";
RL Genome Biol. 4:R45.1-R45.13(2003).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=32801125; DOI=10.1242/jcs.245555;
RA Uemura S., Mochizuki T., Amemiya K., Kurosaka G., Yazawa M., Nakamoto K.,
RA Ishikawa Y., Izawa S., Abe F.;
RT "Amino acid homeostatic control by TORC1 in Saccharomyces cerevisiae under
RT high hydrostatic pressure.";
RL J. Cell Sci. 133:jcs245555-jcs245555(2020).
CC -!- DISRUPTION PHENOTYPE: Sensitive to high hydrostatic pressure
CC (mechanical stress). {ECO:0000269|PubMed:32801125}.
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DR EMBL; X59720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK006937; DAA07547.1; -; Genomic_DNA.
DR RefSeq; NP_878058.1; NM_001184529.1.
DR PDB; 4XPM; X-ray; 2.40 A; B=1-75.
DR PDB; 6JWP; X-ray; 3.20 A; D/I=1-75.
DR PDBsum; 4XPM; -.
DR PDBsum; 6JWP; -.
DR AlphaFoldDB; Q3E830; -.
DR SMR; Q3E830; -.
DR BioGRID; 36945; 65.
DR ComplexPortal; CPX-3172; EGO complex.
DR STRING; 4932.YCR075W-A; -.
DR MaxQB; Q3E830; -.
DR PaxDb; Q3E830; -.
DR PRIDE; Q3E830; -.
DR EnsemblFungi; YCR075W-A_mRNA; YCR075W-A; YCR075W-A.
DR GeneID; 1466399; -.
DR KEGG; sce:YCR075W-A; -.
DR SGD; S000028519; EGO2.
DR VEuPathDB; FungiDB:YCR075W-A; -.
DR HOGENOM; CLU_173479_2_0_1; -.
DR InParanoid; Q3E830; -.
DR OMA; TIAFDTH; -.
DR BioCyc; YEAST:G3O-29425-MON; -.
DR PRO; PR:Q3E830; -.
DR Proteomes; UP000002311; Chromosome III.
DR RNAct; Q3E830; protein.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
DR GO; GO:0071986; C:Ragulator complex; IPI:SGD.
DR GO; GO:0016237; P:lysosomal microautophagy; IC:ComplexPortal.
DR GO; GO:0032008; P:positive regulation of TOR signaling; IC:ComplexPortal.
DR GO; GO:0072665; P:protein localization to vacuole; IMP:SGD.
DR GO; GO:0038202; P:TORC1 signaling; IMP:SGD.
DR Gene3D; 3.40.1840.10; -; 1.
DR InterPro; IPR021591; DUF3215.
DR InterPro; IPR035098; YNR034W-A-like.
DR Pfam; PF11503; DUF3215; 1.
DR SUPFAM; SSF160683; SSF160683; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..75
FT /note="Protein EGO2"
FT /id="PRO_0000248451"
FT STRAND 11..16
FT /evidence="ECO:0007829|PDB:4XPM"
FT STRAND 17..19
FT /evidence="ECO:0007829|PDB:6JWP"
FT STRAND 21..26
FT /evidence="ECO:0007829|PDB:4XPM"
FT HELIX 27..30
FT /evidence="ECO:0007829|PDB:4XPM"
FT HELIX 32..34
FT /evidence="ECO:0007829|PDB:4XPM"
FT HELIX 35..38
FT /evidence="ECO:0007829|PDB:4XPM"
FT STRAND 47..63
FT /evidence="ECO:0007829|PDB:4XPM"
FT STRAND 66..73
FT /evidence="ECO:0007829|PDB:4XPM"
SQ SEQUENCE 75 AA; 8097 MW; BB142B30B04DDE16 CRC64;
MEAEKQSDIK GTIAFDTHGN VIESTGVGSQ RIEDIGDLSK VTLDAEGFAQ VQGDSLLVHL
YKRNDITLAV YTSAQ
