EGON_DROME
ID EGON_DROME Reviewed; 373 AA.
AC P15370; Q0IGS4; Q9VNY0;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 186.
DE RecName: Full=Protein embryonic gonad;
DE AltName: Full=Nuclear receptor subfamily 0 group A member 3;
DE AltName: Full=Protein eagle;
DE AltName: Full=Protein spready;
GN Name=eg; Synonyms=egon, NR0A3, spry; ORFNames=CG7383;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2555153; DOI=10.1002/j.1460-2075.1989.tb08460.x;
RA Rothe M., Nauber U., Jaeckle H.;
RT "Three hormone receptor-like Drosophila genes encode an identical DNA-
RT binding finger.";
RL EMBO J. 8:3087-3094(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=Canton-S;
RX PubMed=8625804; DOI=10.1242/dev.122.2.527;
RA Higashijima S., Shishido E., Matsuzaki M., Saigo K.;
RT "Eagle, a member of the steroid receptor gene superfamily, is expressed in
RT a subset of neuroblasts and regulates the fate of their putative progeny in
RT the Drosophila CNS.";
RL Development 122:527-536(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a critical role in development of the progeny of
CC eagle-positive neuroblasts. {ECO:0000269|PubMed:8625804}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- TISSUE SPECIFICITY: During embryonic stages 10 and 11, expression was
CC observed in four neuroblasts, NB2-4, NB3-3, NB6-4 and NB7-3. Except for
CC NB6-4, expression reaches a maximum at the very beginning of expression
CC or in the period of neuroblast delamination. Weak expression is also
CC observed in a few putative progeny of NB7-3 during late embryonic stage
CC 11 and 12. All eagle expression in abdominal segments disappears by
CC stage 13. {ECO:0000269|PubMed:8625804}.
CC -!- DISRUPTION PHENOTYPE: EG cells fail to acquire the neural fate or
CC underwent an extremely delayed differentiation, while EW neurons
CC produced neurites in abnormal directions. {ECO:0000269|PubMed:8625804}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR0
CC subfamily. {ECO:0000305}.
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DR EMBL; X16631; CAA34626.1; -; mRNA.
DR EMBL; D43634; BAA07742.1; -; mRNA.
DR EMBL; D43635; BAA07743.1; -; mRNA.
DR EMBL; AE014296; AAF51783.1; -; Genomic_DNA.
DR EMBL; AE014296; AAN12188.1; -; Genomic_DNA.
DR EMBL; BT028846; ABI34227.2; -; mRNA.
DR PIR; S06010; S06010.
DR RefSeq; NP_524206.1; NM_079482.4.
DR RefSeq; NP_730689.1; NM_168938.2.
DR AlphaFoldDB; P15370; -.
DR SMR; P15370; -.
DR BioGRID; 65668; 22.
DR IntAct; P15370; 16.
DR STRING; 7227.FBpp0078091; -.
DR PaxDb; P15370; -.
DR DNASU; 40428; -.
DR EnsemblMetazoa; FBtr0078437; FBpp0078091; FBgn0000560.
DR EnsemblMetazoa; FBtr0078438; FBpp0078092; FBgn0000560.
DR GeneID; 40428; -.
DR KEGG; dme:Dmel_CG7383; -.
DR CTD; 40428; -.
DR FlyBase; FBgn0000560; eg.
DR VEuPathDB; VectorBase:FBgn0000560; -.
DR eggNOG; ENOG502RZKC; Eukaryota.
DR GeneTree; ENSGT00940000170271; -.
DR HOGENOM; CLU_043709_0_0_1; -.
DR InParanoid; P15370; -.
DR OMA; KYLNDRQ; -.
DR OrthoDB; 1136195at2759; -.
DR PhylomeDB; P15370; -.
DR Reactome; R-DME-1251985; Nuclear signaling by ERBB4.
DR Reactome; R-DME-1257604; PIP3 activates AKT signaling.
DR Reactome; R-DME-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR Reactome; R-DME-383280; Nuclear Receptor transcription pathway.
DR Reactome; R-DME-5625886; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
DR Reactome; R-DME-5689880; Ub-specific processing proteases.
DR Reactome; R-DME-5689896; Ovarian tumor domain proteases.
DR Reactome; R-DME-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR Reactome; R-DME-8931987; RUNX1 regulates estrogen receptor mediated transcription.
DR Reactome; R-DME-8939211; ESR-mediated signaling.
DR Reactome; R-DME-8940973; RUNX2 regulates osteoblast differentiation.
DR Reactome; R-DME-9009391; Extra-nuclear estrogen signaling.
DR Reactome; R-DME-9018519; Estrogen-dependent gene expression.
DR SignaLink; P15370; -.
DR BioGRID-ORCS; 40428; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 40428; -.
DR PRO; PR:P15370; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0000560; Expressed in neuroblast of ventral nerve cord primordium (Drosophila) and 15 other tissues.
DR ExpressionAtlas; P15370; baseline and differential.
DR Genevisible; P15370; DM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007417; P:central nervous system development; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:FlyBase.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Neurogenesis; Nucleus; Receptor; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..373
FT /note="Protein embryonic gonad"
FT /id="PRO_0000053746"
FT DNA_BIND 2..78
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 5..25
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 42..66
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 126..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 325
FT /note="P -> H (in Ref. 1; CAA34626 and 2; BAA07742/
FT BAA07743)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 373 AA; 39561 MW; 137494333A9A5760 CRC64;
MNQLCKVCGE PAAGFHFGAF TCEGCKSFFG RTYNNIAAIA GCKHNGDCVI NKKNRTACKA
CRLRKCLLVG MSKSGSRYGR RSNWFKIHCL LQEQQTTSGL GGGSSVGSGS GGGVSSASLE
QLARLQQASN QARQTYQDKT NPCIKSATAT TSPRIEGAAV GTGIGGGASP SFLQAAKLHH
QRQLKLDSRL SNTPSDSGAS SAGDPNEDGV TSVLGGQIAT PSSTNATSLP KLDLRHPNFP
ATSEPDADMQ RQRHQELLEI FRSHSEPLYS SFAPFSHLPP VLLAAGVPQL PIFKDQFKAE
LLFPTTSSPE LEEPIDLSFR SRADPASPMA HNSNSPSLSE PAAASHCLGE STNFVRKSTP
LDLTLVRSQT LTG
