ID   EGR2_POERE              Reviewed;          62 AA.
AC   P26635;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Early growth response protein 2;
DE            Short=EGR-2;
DE   AltName: Full=Zinc finger protein Krox-20;
DE   Flags: Fragment;
GN   Name=egr2;
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1930167; DOI=10.1016/0006-291x(91)91702-e;
RA   Lanfear J., Jowett T., Holland P.W.;
RT   "Cloning of fish zinc-finger genes related to Krox-20 and Krox-24.";
RL   Biochem. Biophys. Res. Commun. 179:1220-1224(1991).
CC   -!- FUNCTION: Sequence-specific DNA-binding transcription factor. Binds to
CC       two specific DNA sites located in the promoter region of HOXA4.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; M81107; AAA49446.1; -; Genomic_DNA.
DR   PIR; PQ0234; PQ0234.
DR   AlphaFoldDB; P26635; -.
DR   SMR; P26635; -.
DR   STRING; 8081.XP_008436442.1; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           <1..>62
FT                   /note="Early growth response protein 2"
FT                   /id="PRO_0000047122"
FT   ZN_FING         <1..21
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         27..49
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         55..>62
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   NON_TER         1
FT   NON_TER         62
SQ   SEQUENCE   62 AA;  7247 MW;  FF07B94A8920BF76 CRC64;
     AEGCDRGFSR SDELTRHIRI HTGHKPFQCR ICMRNFSRSD HLTTHIRTHT GEKPFACDYC
     GR