ID   EGR2_XENLA              Reviewed;         421 AA.
AC   Q08427;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Early growth response protein 2;
DE            Short=EGR-2;
DE   AltName: Full=Zinc finger protein Krox-20;
GN   Name=egr2; Synonyms=krox20;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=8443108; DOI=10.1016/0925-4773(93)90089-g;
RA   Bradley L.C., Snape A., Bhatt S., Wilkinson D.G.;
RT   "The structure and expression of the Xenopus Krox-20 gene: conserved and
RT   divergent patterns of expression in rhombomeres and neural crest.";
RL   Mech. Dev. 40:73-84(1993).
CC   -!- FUNCTION: Sequence-specific DNA-binding transcription factor.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; S56884; AAB25681.1; -; mRNA.
DR   PIR; A56550; A56550.
DR   RefSeq; NP_001079248.1; NM_001085779.1.
DR   AlphaFoldDB; Q08427; -.
DR   GeneID; 378520; -.
DR   KEGG; xla:378520; -.
DR   CTD; 378520; -.
DR   Xenbase; XB-GENE-866474; egr2.L.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 378520; Expressed in brain and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR021849; EGR_N.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF11928; DUF3446; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..421
FT                   /note="Early growth response protein 2"
FT                   /id="PRO_0000047123"
FT   ZN_FING         288..312
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         318..340
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         346..368
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          127..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  46380 MW;  BE5733BE61713781 CRC64;
     MAAKAVDKLP VTFGSFVHQI PEGFYPGEDS TLPASVTIFP NVDLGGPLIQ MSGVTGDGMI
     SVDMNNDKRS LDFSYSSNYP LAPRTQPIAY MGKISIDHQY SGSGWNTEGI FNLVSAASLL
     GVPPSSCSST SSSNASSGSP NLSCSMSHPQ SDLEHIYSPP PYSSCNEIYQ DPLRFPCGSP
     TAASLPPPPS YPSPKGASDG GMFPMIPDYS ALFPPQCQRD LHSDRKPFPC PRHPSPLSTI
     RNFTLGGSSE GPRLASAYSP QNLPLRPILR PRKYPNRPSK TPVHERPYPC PAEGCDRRFS
     RSDELTRHIR IHTGHKPFQC RICMRNFSRS DHLTTHIRTH TGEKPFACDY CGRKFARSDE
     RKRHTKIHLR QKERKNSATA AWRQHVARTS LKPQSGRDRQ PCALLGPAAA HWDSIDPNRT
     G