EGR3_MOUSE
ID EGR3_MOUSE Reviewed; 387 AA.
AC P43300; Q9R276;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 09-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Early growth response protein 3;
DE Short=EGR-3;
GN Name=Egr3; Synonyms=Egr-3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9731539; DOI=10.1038/1757;
RA Tourtellotte W.G., Milbrandt J.;
RT "Sensory ataxia and muscle spindle agenesis in mice lacking the
RT transcription factor Egr3.";
RL Nat. Genet. 20:87-91(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 32-327.
RX PubMed=1906159;
RA Patwardhan S., Gashler A., Siegel M.G., Chang L.C., Joseph L.J.,
RA Shows T.B., le Beau M.M., Sukhatme V.P.;
RT "EGR3, a novel member of the Egr family of genes encoding immediate-early
RT transcription factors.";
RL Oncogene 6:917-928(1991).
CC -!- FUNCTION: Probable transcription factor involved in muscle spindle
CC development.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; AF132128; AAD28261.1; -; mRNA.
DR EMBL; S40835; AAB19318.1; -; mRNA.
DR CCDS; CCDS27246.1; -.
DR PIR; B43819; B43819.
DR RefSeq; NP_061251.1; NM_018781.3.
DR AlphaFoldDB; P43300; -.
DR SMR; P43300; -.
DR STRING; 10090.ENSMUSP00000037042; -.
DR PhosphoSitePlus; P43300; -.
DR PaxDb; P43300; -.
DR PRIDE; P43300; -.
DR ProteomicsDB; 277733; -.
DR Antibodypedia; 22692; 240 antibodies from 28 providers.
DR DNASU; 13655; -.
DR Ensembl; ENSMUST00000225200; ENSMUSP00000153491; ENSMUSG00000033730.
DR GeneID; 13655; -.
DR KEGG; mmu:13655; -.
DR UCSC; uc007unb.2; mouse.
DR CTD; 1960; -.
DR MGI; MGI:1306780; Egr3.
DR VEuPathDB; HostDB:ENSMUSG00000033730; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160355; -.
DR HOGENOM; CLU_043235_0_0_1; -.
DR InParanoid; P43300; -.
DR OMA; GEVEPMY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P43300; -.
DR TreeFam; TF318980; -.
DR BioGRID-ORCS; 13655; 0 hits in 72 CRISPR screens.
DR PRO; PR:P43300; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; P43300; protein.
DR Bgee; ENSMUSG00000033730; Expressed in prefrontal cortex and 164 other tissues.
DR ExpressionAtlas; P43300; baseline and differential.
DR Genevisible; P43300; MM.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; ISO:MGI.
DR GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; ISO:MGI.
DR GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; ISO:MGI.
DR GO; GO:0035767; P:endothelial cell chemotaxis; ISO:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; IMP:MGI.
DR GO; GO:0007422; P:peripheral nervous system development; IMP:MGI.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:MGI.
DR GO; GO:0033089; P:positive regulation of T cell differentiation in thymus; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045586; P:regulation of gamma-delta T cell differentiation; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR021849; EGR_N.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF11928; DUF3446; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..387
FT /note="Early growth response protein 3"
FT /id="PRO_0000047126"
FT ZN_FING 275..299
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 305..327
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 333..355
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 241..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 324..325
FT /note="IR -> TH (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 387 AA; 42635 MW; D6EE31B8D4F26949 CRC64;
MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVAHYNQMA TENVMDIGLT
NEKPNPELSY SSSFQPAPGN KTVTYLGKFA FDSPSNWCQD NIISLMSAGI LGVPPASGAL
STQTSTASMV QPPQGDVEAM YPALPPYSNC GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK
PALDSNLFPM IPDYNLYHHP NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH
PGFGSLPQPP LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT
GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR HAKIHLKQKE
KKSEKGGAPS ASSAPTVSLA PVVTTCA
