ID   EGR4_MOUSE              Reviewed;         478 AA.
AC   Q9WUF2;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=Early growth response protein 4;
DE            Short=EGR-4;
GN   Name=Egr4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10529423; DOI=10.1242/dev.126.22.5061;
RA   Tourtellotte W.G., Nagarajan R., Auyeung A., Mueller C., Milbrandt J.;
RT   "Infertility associated with incomplete spermatogenic arrest and
RT   oligozoospermia in Egr4-deficient mice.";
RL   Development 126:5061-5071(1999).
CC   -!- FUNCTION: Transcriptional regulator. Recognizes and binds to the DNA
CC       sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target
CC       genes whose products are required for mitogenesis and differentiation
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF132613; AAD28267.1; -; Genomic_DNA.
DR   CCDS; CCDS20297.1; -.
DR   RefSeq; NP_065621.1; NM_020596.2.
DR   AlphaFoldDB; Q9WUF2; -.
DR   SMR; Q9WUF2; -.
DR   STRING; 10090.ENSMUSP00000093433; -.
DR   iPTMnet; Q9WUF2; -.
DR   PhosphoSitePlus; Q9WUF2; -.
DR   PaxDb; Q9WUF2; -.
DR   PRIDE; Q9WUF2; -.
DR   Antibodypedia; 16536; 120 antibodies from 27 providers.
DR   DNASU; 13656; -.
DR   Ensembl; ENSMUST00000095759; ENSMUSP00000093433; ENSMUSG00000071341.
DR   GeneID; 13656; -.
DR   KEGG; mmu:13656; -.
DR   UCSC; uc009cpy.1; mouse.
DR   CTD; 1961; -.
DR   MGI; MGI:99252; Egr4.
DR   VEuPathDB; HostDB:ENSMUSG00000071341; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000162199; -.
DR   HOGENOM; CLU_044356_0_0_1; -.
DR   InParanoid; Q9WUF2; -.
DR   OMA; LYKWGGC; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q9WUF2; -.
DR   TreeFam; TF318980; -.
DR   BioGRID-ORCS; 13656; 2 hits in 73 CRISPR screens.
DR   PRO; PR:Q9WUF2; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q9WUF2; protein.
DR   Bgee; ENSMUSG00000071341; Expressed in superior frontal gyrus and 32 other tissues.
DR   ExpressionAtlas; Q9WUF2; baseline and differential.
DR   Genevisible; Q9WUF2; MM.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..478
FT                   /note="Early growth response protein 4"
FT                   /id="PRO_0000047129"
FT   ZN_FING         372..396
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         402..424
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         430..452
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          275..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   478 AA;  49554 MW;  495926882CE4E371 CRC64;
     MLHLSDFSGS DALLSKPTEG CAHASPELPR LPARDAPSAA AYPGGDFLSW ALSSCGAGGD
     LTDSCFLEGP APTPPSGLSY SGSFFIQAVP EHPHDPEALF NLMSGILGLA PFPGPEAAAS
     RSPLDVPFPA GPDALLPDLY SPDLSSAAFP EAFWEAAPSA GAPSQCLFEP QLSPPDVKPG
     LRAPPASPAL DAAASAFKGP YAPWELLSAG VPGNCGSQGS FQTTPEARFS AVGTKVEDLL
     SISCPAELPG PAARLYQAGA YDTFSLAPGD LGEGTEGLPA LLTPPGGEGG SGGEGGEFLA
     APPAQLSPLG LRGAATADFS KPLVADLPGG SGVAAPSSPA ASFPAAKARR KGRRGGKCSA
     RCFCPRPHVK AFACPVESCV RSFARSDELN RHLRIHTGHK PFQCRICLRN FSRSDHLTTH
     VRTHTGEKPF ACDVCGRRFA RSDEKKRHSK VHLKQKARAE ERLKGLGFYS LGLSFAAL