ID   EGR4_RAT                Reviewed;         478 AA.
AC   Q00911;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 140.
DE   RecName: Full=Early growth response protein 4;
DE            Short=EGR-4;
DE   AltName: Full=Early response protein NGFI-C;
DE   AltName: Full=Nerve growth factor-induced protein C;
DE            Short=NGFI-C;
GN   Name=Egr4; Synonyms=Egr-4, Ngfic;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
RX   PubMed=2072895; DOI=10.1128/mcb.11.8.3835-3841.1991;
RA   Crosby S.D., Puetz J.J., Simburger K.S., Fahrner T.J., Milbrandt J.;
RT   "The early response gene NGFI-C encodes a zinc finger transcriptional
RT   activator and is a member of the GCGGGGGCG (GSG) element-binding protein
RT   family.";
RL   Mol. Cell. Biol. 11:3835-3841(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1584812; DOI=10.1073/pnas.89.10.4739;
RA   Crosby S.D., Veile R.A., Donis-Keller H., Baraban J.M., Bhat R.V.,
RA   Simburger K.S., Milbrandt J.;
RT   "Neural-specific expression, genomic structure, and chromosomal
RT   localization of the gene encoding the zinc-finger transcription factor
RT   NGFI-C.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:4739-4743(1992).
CC   -!- FUNCTION: Transcriptional regulator. Recognizes and binds to the DNA
CC       sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target
CC       genes whose products are required for mitogenesis and differentiation.
CC       {ECO:0000269|PubMed:2072895}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- INDUCTION: By nerve growth factor. {ECO:0000269|PubMed:2072895}.
CC   -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; M65008; AAA41698.1; -; mRNA.
DR   EMBL; M92433; AAA41699.1; -; Genomic_DNA.
DR   PIR; A45285; A45285.
DR   RefSeq; NP_062010.1; NM_019137.1.
DR   AlphaFoldDB; Q00911; -.
DR   SMR; Q00911; -.
DR   STRING; 10116.ENSRNOP00000021097; -.
DR   PhosphoSitePlus; Q00911; -.
DR   PaxDb; Q00911; -.
DR   GeneID; 25129; -.
DR   KEGG; rno:25129; -.
DR   UCSC; RGD:2546; rat.
DR   CTD; 1961; -.
DR   RGD; 2546; Egr4.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; Q00911; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q00911; -.
DR   PRO; PR:Q00911; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:RGD.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0071363; P:cellular response to growth factor stimulus; IEP:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..478
FT                   /note="Early growth response protein 4"
FT                   /id="PRO_0000047130"
FT   ZN_FING         372..396
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         402..424
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         430..452
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          15..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   478 AA;  49668 MW;  F85C48E7B37040F4 CRC64;
     MLHLSDFSGP DALLSKPTEG CAHTSPELPR LPARDAPSAA AYPGGDFLSW ALSTCGAGGD
     LTDSCFLEGP APTPPSGLSY SGSFFIQAVP EHPHDPEALF NLMSGILGLA PFPSPEAAAS
     RSPLDVPFPA GPDALLPDLY SPDLSSAAFP EAFWEAAPSA GAPSQCLFEP QLSPPDVKPG
     LRAPPASPAL DAAASAFKGP YAPWELLSAG APGNCGSQGS FQTTPEARFS AVGTKVEDLL
     SISCPAELPG PASRLYPPGA YDAFSLAPGD LGEGTEGLPA LLTPPGGEGG SGGEGGEFLA
     VPQAQLSPLG LRGAATADFS KALVADLPGG SGVAAPSSPA TSFPAAKARR KGRRGGKCSA
     RCFCPRPHVK AFACPVESCV RTFARSDELN RHLRIHTGHK PFQCRICLRN FSRSDHLTTH
     VRTHTGEKPF ACDVCGRRFA RSDEKKRHSK VHLKQKARAE ERLKGLGFYS LGLSFAAL