EGRH1_CAEEL
ID EGRH1_CAEEL Reviewed; 461 AA.
AC Q18250;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Early growth response factor homolog 1 {ECO:0000303|PubMed:20736289};
GN Name=egrh-1 {ECO:0000312|WormBase:C27C12.2};
GN ORFNames=C27C12.2 {ECO:0000312|WormBase:C27C12.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=20736289; DOI=10.1242/dev.041616;
RA Clary L.M., Okkema P.G.;
RT "The EGR family gene egrh-1 functions non-autonomously in the control of
RT oocyte meiotic maturation and ovulation in C. elegans.";
RL Development 137:3129-3137(2010).
CC -!- FUNCTION: Sequence-specific DNA-binding transcription factor (By
CC similarity). Plays a role in oocyte development, acting cell-
CC autonomously in the somatic gonad (PubMed:20736289). Involved in
CC negative regulation of oocyte MAPK activation and inhibits oocyte
CC maturation and ovulation (PubMed:20736289).
CC {ECO:0000250|UniProtKB:P11161, ECO:0000269|PubMed:20736289}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20736289}. Cytoplasm,
CC perinuclear region {ECO:0000269|PubMed:20736289}. Note=Perinuclear
CC localization only observed in sperm. {ECO:0000269|PubMed:20736289}.
CC -!- TISSUE SPECIFICITY: Expressed in sheath cells and distal tip cells of
CC the somatic gonad, as well as in the intestine and sperm (at protein
CC level) (PubMed:20736289). Expression not observed in oocytes (at
CC protein level) (PubMed:20736289). {ECO:0000269|PubMed:20736289}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes abnormalities in
CC oocyte development, including degrading oocytes in the proximal gonadal
CC arm and ectopic developing oocytes in the distal arm (PubMed:20736289).
CC RNAi-mediated knockdown targeted to the soma, on an rrf-1 mutant
CC background, exhibits only a slight increase in the frequency of oocyte
CC defects (PubMed:20736289). {ECO:0000269|PubMed:20736289}.
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284606; CAA93744.2; -; Genomic_DNA.
DR PIR; T19515; T19515.
DR RefSeq; NP_510462.2; NM_078061.5.
DR AlphaFoldDB; Q18250; -.
DR SMR; Q18250; -.
DR STRING; 6239.C27C12.2; -.
DR EPD; Q18250; -.
DR PaxDb; Q18250; -.
DR PeptideAtlas; Q18250; -.
DR EnsemblMetazoa; C27C12.2.1; C27C12.2.1; WBGene00007772.
DR GeneID; 181580; -.
DR KEGG; cel:CELE_C27C12.2; -.
DR UCSC; C27C12.2; c. elegans.
DR CTD; 181580; -.
DR WormBase; C27C12.2; CE40601; WBGene00007772; egrh-1.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000169836; -.
DR HOGENOM; CLU_552347_0_0_1; -.
DR InParanoid; Q18250; -.
DR OMA; KMPLQDR; -.
DR OrthoDB; 1318335at2759; -.
DR Reactome; R-CEL-9031628; NGF-stimulated transcription.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00007772; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043407; P:negative regulation of MAP kinase activity; IMP:WormBase.
DR GO; GO:1900194; P:negative regulation of oocyte maturation; IMP:WormBase.
DR GO; GO:0060280; P:negative regulation of ovulation; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..461
FT /note="Early growth response factor homolog 1"
FT /id="PRO_0000453359"
FT ZN_FING 374..398
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 404..426
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 432..454
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 51402 MW; CA161A6CD5AB87AF CRC64;
MALHEPPSKL NRHSHSNLLK PPSLNKPILT FADNDCLKTP TMNDMLKTPT VNSPRHTPMN
IDGTPKVNGF SGFTPQTDQK FFGEHEPLFN QMHTTTLMPA PSSSYKEPAY SSEQPSSSSD
EAKPKELLGS NSFGVPRMTN GNSKQKPEEL TLKDIEISST GPGGVDSPGL SAAMFQFSPM
VEHFLQNLTN KAGLPELVVD SKTAGLNHQE PSDLIKSVQV RRSSIEDQKF SDVLHVPTLP
RKTSEPSHLG SSLQNEHPQS NSRPSTVIPR VQRTNTSASL TRSMDHSSMS PISAHDDPYS
NSASYSSLST HTSFSDSASL AHFEPKTEPM DDYSYNFSDN DFNSFEFSST SEELKNIGCQ
KMKSSKMPLQ DRPYKCPRDG CDRRFSRSDE LTRHIRIHTG QKPFQCRICM RAFSRSDHLT
THVRTHTGEK PFSCDICGRK FARSDERKRH TKVHKTSRSG S
