ID   EHF_BOVIN               Reviewed;         300 AA.
AC   Q32LN0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=ETS homologous factor;
DE   AltName: Full=ETS domain-containing transcription factor;
GN   Name=EHF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator that may play a role in regulating
CC       epithelial cell differentiation and proliferation. May act as a
CC       repressor for a specific subset of ETS/AP-1-responsive genes, and as a
CC       modulator of the nuclear response to mitogen-activated protein kinase
CC       signaling cascades. Binds to DNA sequences containing the consensus
CC       nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5
CC       expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC   -!- DOMAIN: The PNT domain acts as a transcriptional activator.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC109503; AAI09504.1; -; mRNA.
DR   RefSeq; NP_001033125.1; NM_001038036.2.
DR   RefSeq; XP_005216430.1; XM_005216373.3.
DR   AlphaFoldDB; Q32LN0; -.
DR   SMR; Q32LN0; -.
DR   STRING; 9913.ENSBTAP00000022792; -.
DR   PaxDb; Q32LN0; -.
DR   Ensembl; ENSBTAT00000022792; ENSBTAP00000022792; ENSBTAG00000017150.
DR   GeneID; 505422; -.
DR   KEGG; bta:505422; -.
DR   CTD; 26298; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017150; -.
DR   VGNC; VGNC:28375; EHF.
DR   eggNOG; KOG3804; Eukaryota.
DR   GeneTree; ENSGT00940000159310; -.
DR   HOGENOM; CLU_048172_0_0_1; -.
DR   InParanoid; Q32LN0; -.
DR   OMA; SWTDGYP; -.
DR   OrthoDB; 837296at2759; -.
DR   TreeFam; TF318679; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000017150; Expressed in prostate gland and 76 other tissues.
DR   ExpressionAtlas; Q32LN0; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0030855; P:epithelial cell differentiation; IEA:InterPro.
DR   GO; GO:0050673; P:epithelial cell proliferation; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR033071; EHF.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   PANTHER; PTHR11849:SF171; PTHR11849:SF171; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..300
FT                   /note="ETS homologous factor"
FT                   /id="PRO_0000287132"
FT   DOMAIN          29..115
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        207..289
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          179..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..197
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   300 AA;  35004 MW;  F20E8A1F0184DB86 CRC64;
     MILEGSGVMN LNPSNNLLHQ QPTWTDSYST CNVSSGFFGG QWHEIHPQYW TKYQVWEWLQ
     HLLDTNQLDA SCIPFQEFDV NGEHLCSMSL QEFTRAAGTA GQLLYSNLQH LKWNGQCSSD
     LFQSTHNVIV KTEQTDPSIM NTWKEENYLY DTNYGSTVDL LDSKTFCRAQ ISMTTTGHLP
     IAESPDTKKE QDHPTKPHTK KHNPRGTHLW EFIRDILLNP DKNPGLIKWE DRSEGIFRFL
     KSEAVAQLWG KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN