ID   EHF_PANPA               Reviewed;         300 AA.
AC   A1YG61;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=ETS homologous factor;
DE   AltName: Full=ETS domain-containing transcription factor;
GN   Name=EHF;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator that may play a role in regulating
CC       epithelial cell differentiation and proliferation. May act as a
CC       repressor for a specific subset of ETS/AP-1-responsive genes, and as a
CC       modulator of the nuclear response to mitogen-activated protein kinase
CC       signaling cascades. Binds to DNA sequences containing the consensus
CC       nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5
CC       expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC   -!- DOMAIN: The PNT domain acts as a transcriptional activator.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ977224; ABM54286.1; -; Genomic_DNA.
DR   RefSeq; XP_008954101.1; XM_008955853.2.
DR   AlphaFoldDB; A1YG61; -.
DR   SMR; A1YG61; -.
DR   STRING; 9597.XP_003830425.1; -.
DR   Ensembl; ENSPPAT00000048390; ENSPPAP00000025562; ENSPPAG00000035904.
DR   GeneID; 100992280; -.
DR   CTD; 26298; -.
DR   eggNOG; KOG3804; Eukaryota.
DR   GeneTree; ENSGT00940000159310; -.
DR   OrthoDB; 837296at2759; -.
DR   Proteomes; UP000240080; Chromosome 11.
DR   Bgee; ENSPPAG00000035904; Expressed in adult mammalian kidney and 1 other tissue.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0050673; P:epithelial cell proliferation; IEA:InterPro.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR033071; EHF.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   PANTHER; PTHR11849:SF171; PTHR11849:SF171; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..300
FT                   /note="ETS homologous factor"
FT                   /id="PRO_0000285518"
FT   DOMAIN          29..115
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        207..289
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          183..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   300 AA;  34863 MW;  42EFAAA64DDBD0D5 CRC64;
     MILEGGGVMN LNPGNNLLHQ PPTWTDSYST CNVSSGFFGG QWHEIHPQYW TKYQVWEWLQ
     HLLDTNQLDA SCIPFQEFDI NGEHLCSMSL QEFTRAAGTA GQLLYSNLQH LKWNGQCSSD
     LFQSTHNVIV KTEQTEPSIV NTWKDENYLY DTNYGSTVDL LDSKTFCRAQ ISMTTTSHLP
     VAESPDMKKE QDPPAKCHTK KHNPRGTHLW EFIRDILLNP DKNPGLIKWE DRSEGVFRFL
     KSEAVAQLWG KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN